C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2-alpha kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000172071 EIF2AK3 9606 - 2:88556741-88627576 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000303236 EIF2AK3-001 88556743-88627576 protein_coding
  ENST00000415570 EIF2AK3-004 88557854-88595857 protein_coding
  ENST00000419748 EIF2AK3-003 88556741-88624929 protein_coding
  ENST00000470706 EIF2AK3-007 88570920-88575408 processed_transcript
  ENST00000477083 EIF2AK3-005 88590819-88594078 processed_transcript
  ENST00000478003 EIF2AK3-006 88575383-88579969 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000303236ENST00000415570ENST00000419748ENST00000470706ENST00000477083
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000303236 1.509±0.00 N/A 0.741±0.00 0.742±0.26 1.430±0.81 2.605±0.43 0.596±0.07 2.416±1.20 1.407±0.95 2.202±0.97 0.976±0.11 2.827±1.54 2.834±0.99 0.698±0.08
ENST00000415570 0.992±0.00 N/A 1.025±0.00 N/A 2.121±1.22 2.319±0.00 0.900±0.00 N/A 2.437±0.00 2.528±0.00 N/A N/A 1.398±0.00 0.955±0.39
ENST00000419748 N/A 1.609±0.00 N/A 0.390±0.00 0.857±0.16 N/A N/A N/A N/A N/A 0.684±0.00 N/A N/A 0.948±0.33
ENST00000470706 N/A N/A N/A N/A 9.721±0.00 N/A N/A N/A N/A N/A N/A 8.701±0.00 8.580±0.00 4.974±0.00
ENST00000477083 N/A N/A 4.456±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 ISS skeletal system development
GO:0001503 IMP ossification
GO:0002063 ISS chondrocyte development
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0004694 IDA eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005623 IEA cell
GO:0005737 ISS cytoplasm
GO:0005783 ISS endoplasmic reticulum
GO:0005789 ISS endoplasmic reticulum membrane
GO:0006412 IEA translation
GO:0006468 ISS:IEA protein phosphorylation
GO:0006919 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 IDA ER overload response
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007029 ISS endoplasmic reticulum organization
GO:0007595 IEA lactation
GO:0009967 IEA positive regulation of signal transduction
GO:0010629 IEA negative regulation of gene expression
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017148 TAS negative regulation of translation
GO:0019217 IEA regulation of fatty acid metabolic process
GO:0019722 ISS calcium-mediated signaling
GO:0019899 IPI enzyme binding
GO:0019903 IPI protein phosphatase binding
GO:0030073 ISS insulin secretion
GO:0030282 ISS bone mineralization
GO:0030968 IDA endoplasmic reticulum unfolded protein response
GO:0031016 IEA pancreas development
GO:0031018 IMP endocrine pancreas development
GO:0031642 ISS negative regulation of myelination
GO:0032055 IEA negative regulation of translation in response to stress
GO:0032057 TAS negative regulation of translational initiation in response to stress
GO:0032092 IEA positive regulation of protein binding
GO:0032933 IEA SREBP signaling pathway
GO:0034976 IMP response to endoplasmic reticulum stress
GO:0042802 IPI identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0044267 TAS cellular protein metabolic process
GO:0045444 IEA fat cell differentiation
GO:0046777 IDA protein autophosphorylation
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0051260 IMP protein homooligomerization
GO:0070059 IEA intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902237 IEA positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062139 eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 protein_coding Danio_rerio
ENSMUSG00000031668 Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 protein_coding Mus_musculus

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