C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2 alpha kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000031668 Eif2ak3 10090 + 6:70844515-70905245 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034093 Eif2ak3-001 70844515-70905245 protein_coding
  ENSMUST00000159401 Eif2ak3-003 70878561-70893436 retained_intron
  ENSMUST00000161316 Eif2ak3-004 70896764-70900258 retained_intron
  ENSMUST00000162950 Eif2ak3-002 70844553-70864825 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034093ENSMUST00000161316ENSMUST00000162950
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034093 5.626±1.23 3.914±1.01 5.204±2.31 6.276±0.33 6.722±0.91 10.723±1.54 1.896±0.46 7.646±0.55 3.302±0.68 8.459±0.39 0.938±0.19 7.814±1.20 14.085±5.35 0.882±0.31
ENSMUST00000161316 N/A N/A N/A 31.647±0.00 N/A N/A N/A N/A N/A N/A N/A 35.427±0.00 74.902±0.00 3.625±0.00
ENSMUST00000162950 N/A 7.753±4.20 N/A N/A 5.446±0.66 5.526±1.37 N/A N/A N/A N/A N/A 5.756±1.30 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004QR CIL_0004QR_0002 CGP 6:70765720-70905245

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001501 IMP skeletal system development
GO:0001503 IEA ossification
GO:0002063 IMP chondrocyte development
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004694 IEA eukaryotic translation initiation factor 2alpha kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005623 IEA cell
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0006412 IDA translation
GO:0006468 IMP protein phosphorylation
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 IEA ER overload response
GO:0007029 IMP endoplasmic reticulum organization
GO:0007595 IMP lactation
GO:0009967 IDA positive regulation of signal transduction
GO:0010629 IMP negative regulation of gene expression
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0017148 IMP negative regulation of translation
GO:0019217 IMP regulation of fatty acid metabolic process
GO:0019722 IMP calcium-mediated signaling
GO:0019899 IEA enzyme binding
GO:0019903 IEA protein phosphatase binding
GO:0030282 IMP bone mineralization
GO:0030968 IMP endoplasmic reticulum unfolded protein response
GO:0031016 IMP pancreas development
GO:0031018 IEA endocrine pancreas development
GO:0031642 IMP negative regulation of myelination
GO:0032055 IEA negative regulation of translation in response to stress
GO:0032092 IMP positive regulation of protein binding
GO:0032933 IDA SREBP signaling pathway
GO:0034976 IEA response to endoplasmic reticulum stress
GO:0042802 IEA identical protein binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0045444 IDA fat cell differentiation
GO:0046777 IMP protein autophosphorylation
GO:0048009 IMP insulin-like growth factor receptor signaling pathway
GO:0051260 IEA protein homooligomerization
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902237 IGI positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062139 eif2ak3 eukaryotic translation initiation factor 2-alpha kinase 3 protein_coding Danio_rerio
ENSG00000172071 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 protein_coding Homo_sapiens

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