C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase kinase kinase 11
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173327 MAP3K11 9606 - 11:65597755-65615382 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309100 MAP3K11-001 65597755-65614242 protein_coding
  ENST00000524848 MAP3K11-005 65597758-65608422 nonsense_mediated_decay
  ENST00000524856 MAP3K11-002 65606435-65615382 retained_intron
  ENST00000526293 MAP3K11-012 65607802-65614249 protein_coding
  ENST00000526647 MAP3K11-007 65605722-65606396 retained_intron
  ENST00000527304 MAP3K11-003 65608632-65614236 retained_intron
  ENST00000529839 MAP3K11-013 65607930-65614248 protein_coding
  ENST00000530153 MAP3K11-004 65597756-65611301 protein_coding
  ENST00000530949 MAP3K11-011 65607706-65608448 retained_intron
  ENST00000532507 MAP3K11-006 65597756-65607026 protein_coding
  ENST00000533032 MAP3K11-009 65607165-65607870 retained_intron
  ENST00000534110 MAP3K11-010 65608024-65608805 retained_intron
  ENST00000534432 MAP3K11-008 65599451-65606758 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309100ENST00000524848ENST00000527304ENST00000530153ENST00000532507ENST00000533032ENST00000534110
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309100 40.885±0.00 25.022±0.00 0.996±0.00 7.409±5.93 12.793±10.29 10.813±8.52 4.630±3.93 11.513±7.94 9.682±7.80 24.032±22.48 3.123±2.78 12.899±8.73 31.467±14.25 7.254±5.01
ENST00000524848 N/A 12.349±0.00 N/A N/A 13.144±0.00 7.316±0.00 3.154±0.00 8.880±0.00 18.322±0.00 30.295±0.00 1.763±1.45 7.780±0.00 9.754±0.00 N/A
ENST00000527304 N/A N/A N/A N/A 0.514±0.00 0.492±0.00 0.273±0.00 N/A 0.371±0.00 1.009±0.00 N/A 0.249±0.00 N/A N/A
ENST00000530153 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.364±0.00
ENST00000532507 N/A N/A 0.681±0.00 N/A 1.441±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 9.030±5.11
ENST00000533032 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 33.012±0.00 48.803±0.00 14.216±0.00
ENST00000534110 N/A N/A 1.063±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W1 CIL_0008W1_0001 VISTA 11:65187233-65790923

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IMP activation of MAPK activity
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004706 ISS JUN kinase kinase kinase activity
GO:0004709 IEA MAP kinase kinase kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005813 IDA centrosome
GO:0005874 IDA microtubule
GO:0006468 IDA:IEA protein phosphorylation
GO:0007017 IMP microtubule-based process
GO:0007254 TAS JNK cascade
GO:0007256 IEA activation of JNKK activity
GO:0007257 IMP activation of JUN kinase activity
GO:0008219 IEA cell death
GO:0008283 IMP cell proliferation
GO:0016020 IDA membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0031435 IPI mitogen-activated protein kinase kinase kinase binding
GO:0042802 IPI identical protein binding
GO:0042803 IPI protein homodimerization activity
GO:0043065 IEA positive regulation of apoptotic process
GO:0043507 IMP positive regulation of JUN kinase activity
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 IDA protein autophosphorylation
GO:0048365 IEA Rac GTPase binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000091521 MAP3K11 mitogen-activated protein kinase kinase kinase 11 protein_coding Danio_rerio
ENSMUSG00000004054 Map3k11 mitogen-activated protein kinase kinase kinase 11 protein_coding Mus_musculus

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