C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: titin-cap
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173991 TCAP 9606 + 17:39664187-39666555 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000309889 TCAP-001 39664187-39666555 protein_coding
  ENST00000578283 TCAP-002 39665349-39666249 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000309889ENST00000578283
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000309889 0.260±0.00 0.532±0.00 0.178±0.00 0.596±0.38 19.030±18.93 1.313±0.00 280.523±241.90 0.426±0.26 0.271±0.14 0.444±0.39 214.383±9.38 0.773±0.33 1.787±2.12 4.783±4.19
ENST00000578283 0.139±0.00 N/A 0.182±0.00 0.737±0.00 123.147±122.91 1.218±0.00 558.188±502.05 1.135±0.00 0.364±0.00 0.490±0.00 366.785±67.86 0.300±0.00 3.863±4.63 34.437±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008SN CIL_0008SN_0001 VISTA 17:39110111-39710718
CIL_00080Z CIL_00080Z_0001 VISTA 17:39318232-39918735
CIL_00098W CIL_00098W_0001 VISTA 17:39359510-39962707
CIL_0007WH CIL_0007WH_0001 VISTA 17:39374871-39978277
CIL_00023N CIL_00023N_0001 CGP 17:39637065-39666555
CIL_0002BR CIL_0002BR_0001 CGP 17:39664187-39670475

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001756 IEA somitogenesis
GO:0003009 IEP skeletal muscle contraction
GO:0003300 IMP cardiac muscle hypertrophy
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0006461 TAS protein complex assembly
GO:0007512 IMP adult heart development
GO:0008307 IMP structural constituent of muscle
GO:0014898 IMP cardiac muscle hypertrophy in response to stress
GO:0030018 IDA Z disc
GO:0030049 TAS muscle filament sliding
GO:0030240 IMP skeletal muscle thin filament assembly
GO:0030241 IMP skeletal muscle myosin thick filament assembly
GO:0030674 IDA protein binding, bridging
GO:0030916 IEA otic vesicle formation
GO:0031432 IPI titin binding
GO:0031674 ISS I band
GO:0035994 TAS response to muscle stretch
GO:0035995 IMP detection of muscle stretch
GO:0044325 IPI ion channel binding
GO:0045214 TAS sarcomere organization
GO:0048739 IMP cardiac muscle fiber development
GO:0048769 IMP sarcomerogenesis
GO:0050982 TAS detection of mechanical stimulus
GO:0051373 IPI FATZ binding
GO:0055003 IMP cardiac myofibril assembly
GO:0055008 IMP cardiac muscle tissue morphogenesis
GO:0060048 IMP cardiac muscle contraction
GO:0070080 IPI titin Z domain binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007344 tcap titin-cap (telethonin) protein_coding Danio_rerio
ENSMUSG00000007877 Tcap titin-cap protein_coding Mus_musculus

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