C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type IV, beta subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177098 SCN4B 9606 - 11:118133377-118152888 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000324727 SCN4B-001 118133377-118152820 protein_coding
  ENST00000415030 SCN4B-002 118133377-118145433 retained_intron
  ENST00000423160 SCN4B-003 118133379-118142873 processed_transcript
  ENST00000529878 SCN4B-004 118136961-118152888 protein_coding
  ENST00000531550 SCN4B-006 118136573-118141864 retained_intron
  ENST00000532138 SCN4B-005 118141206-118145700 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000324727ENST00000415030ENST00000423160ENST00000531550
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000324727 0.887±0.00 2.779±0.00 N/A 3.602±1.30 5.534±4.74 1.458±0.00 2.745±1.76 0.270±0.00 0.740±0.00 2.378±0.92 1.920±0.11 0.461±0.09 1.433±0.68 1.173±0.80
ENST00000415030 0.220±0.00 N/A N/A 2.973±0.03 N/A N/A N/A N/A N/A 1.251±0.00 N/A 0.661±0.00 N/A N/A
ENST00000423160 N/A 4.775±0.00 0.384±0.00 N/A 3.033±0.00 0.578±0.00 0.176±0.00 0.360±0.06 0.320±0.00 N/A 2.305±0.00 0.295±0.25 N/A 0.388±0.16
ENST00000531550 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.668±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002BW CIL_0002BW_0002 CGP 11:118077012-118152888

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IDA voltage-gated sodium channel complex
GO:0005248 IDA voltage-gated sodium channel activity
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0006814 IDA sodium ion transport
GO:0010765 IDA positive regulation of sodium ion transport
GO:0014704 ISS intercalated disc
GO:0017080 IDA sodium channel regulator activity
GO:0031226 IDA intrinsic component of plasma membrane
GO:0035725 IDA sodium ion transmembrane transport
GO:0044325 IPI ion channel binding
GO:0060048 IMP cardiac muscle contraction
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002 IMP cardiac muscle cell action potential involved in contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086067 IMP AV node cell to bundle of His cell communication
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:2000649 IDA regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060319 scn4bb sodium channel, voltage-gated, type IV, beta b protein_coding Danio_rerio
ENSDARG00000062416 scn4ba sodium channel, voltage-gated, type IV, beta a protein_coding Danio_rerio
ENSMUSG00000046480 Scn4b sodium channel, type IV, beta protein_coding Mus_musculus

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