C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: unc-51 like autophagy activating kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000177169 ULK1 9606 + 12:131894651-131923167 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000321867 ULK1-001 131894651-131923167 protein_coding
  ENST00000537421 ULK1-002 131906490-131909996 retained_intron
  ENST00000540568 ULK1-010 131920067-131922281 retained_intron
  ENST00000540647 ULK1-007 131918302-131921550 retained_intron
  ENST00000541761 ULK1-005 131915943-131919385 retained_intron
  ENST00000542313 ULK1-003 131908619-131909169 retained_intron
  ENST00000544718 ULK1-008 131919241-131921951 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000321867ENST00000540647ENST00000542313
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000321867 10.491±0.00 8.270±0.00 5.255±5.01 5.594±4.94 3.424±2.90 13.801±0.00 4.125±3.83 2.914±2.13 5.105±4.85 17.433±15.35 12.734±7.93 8.390±0.75 11.432±2.08
ENST00000540647 N/A N/A N/A N/A 0.734±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000542313 N/A N/A N/A N/A N/A 1.788±0.00 N/A N/A N/A N/A 3.779±0.00 N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000045 IBA autophagic vacuole assembly
GO:0000407 IEA pre-autophagosomal structure
GO:0003824 IEA catalytic activity
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005737 NAS cytoplasm
GO:0005776 IDA autophagic vacuole
GO:0005829 IDA cytosol
GO:0006468 NAS:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007265 IEA Ras protein signal transduction
GO:0007409 IEA axonogenesis
GO:0008104 IMP protein localization
GO:0009103 IEA lipopolysaccharide biosynthetic process
GO:0010506 IMP regulation of autophagy
GO:0010508 ISS positive regulation of autophagy
GO:0016020 IEA membrane
GO:0016239 IMP positive regulation of macroautophagy
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0017137 IPI Rab GTPase binding
GO:0019901 IEA protein kinase binding
GO:0021707 IEA cerebellar granule cell differentiation
GO:0021933 IEA radial glia guided migration of cerebellar granule cell
GO:0030659 IEA cytoplasmic vesicle membrane
GO:0031102 IEA neuron projection regeneration
GO:0031175 IMP neuron projection development
GO:0031623 IEA receptor internalization
GO:0031669 ISS cellular response to nutrient levels
GO:0032403 IPI protein complex binding
GO:0034045 IDA pre-autophagosomal structure membrane
GO:0034273 IBA ATG1/UKL1 signaling complex
GO:0042594 ISS response to starvation
GO:0043005 IEA neuron projection
GO:0043025 IEA neuronal cell body
GO:0046777 IDA protein autophosphorylation
GO:0048671 IEA negative regulation of collateral sprouting
GO:0048675 IBA axon extension
GO:0051386 IEA regulation of neurotrophin TRK receptor signaling pathway
GO:0070969 IPI ULK1-ATG13-FIP200 complex
GO:0097629 IDA extrinsic component of omegasome membrane
GO:0097632 IDA extrinsic component of pre-autophagosomal structure membrane
GO:0097635 IDA extrinsic component of autophagic vacuole membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062518 ulk1a unc-51-like kinase 1a (C. elegans) protein_coding Danio_rerio
ENSDARG00000074481 ulk1b unc-51-like kinase 1b (C. elegans) protein_coding Danio_rerio
ENSMUSG00000029512 Ulk1 unc-51 like kinase 1 protein_coding Mus_musculus

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