C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000180370 PAK2 9606 + 3:196739857-196832647 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000327134 PAK2-001 196739857-196832647 protein_coding
  ENST00000426668 PAK2-004 196812218-196828429 protein_coding
  ENST00000481344 PAK2-003 196806579-196808044 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000327134ENST00000426668
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000327134 20.854±0.00 13.900±0.00 1.971±0.00 7.550±3.31 10.335±2.15 7.249±6.00 5.108±4.15 7.801±4.40 7.889±0.47 12.195±0.95 6.388±4.96 9.481±1.07 14.051±1.01 8.514±1.72
ENST00000426668 N/A N/A N/A N/A 12.827±0.00 N/A N/A N/A N/A N/A 5.255±0.00 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0006469 TAS negative regulation of protein kinase activity
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007015 IEA actin filament organization
GO:0007165 TAS signal transduction
GO:0007411 TAS axon guidance
GO:0016032 TAS viral process
GO:0016310 IDA phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019901 IPI protein kinase binding
GO:0030296 IDA protein tyrosine kinase activator activity
GO:0031295 TAS T cell costimulation
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040008 IEA regulation of growth
GO:0042802 IPI identical protein binding
GO:0042981 TAS regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0050690 TAS regulation of defense response to virus by virus
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050852 TAS T cell receptor signaling pathway
GO:0061098 IDA positive regulation of protein tyrosine kinase activity
GO:2001238 IMP positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 IDA negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018476 pak2b p21 (CDKN1A)-activated kinase 2b protein_coding Danio_rerio
ENSDARG00000068177 pak2a p21 (CDKN1A)-activated kinase 2a protein_coding Danio_rerio
ENSMUSG00000022781 Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 protein_coding Mus_musculus

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