C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: p21 protein (Cdc42/Rac)-activated kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022781 Pak2 10090 - 16:32016290-32079342 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023467 Pak2-001 32016290-32079342 protein_coding
  ENSMUST00000125019 Pak2-002 32033085-32044000 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023467
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023467 14.785±4.34 15.193±2.68 10.437±4.95 11.991±6.50 14.461±4.46 13.956±1.58 5.204±0.55 11.178±0.43 5.963±1.24 19.097±1.31 3.402±0.27 18.508±2.70 15.751±7.39 4.338±1.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003W8 CIL_0003W8_0002 CGP 16:32016290-32099738

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006468 ISO protein phosphorylation
GO:0016020 IEA membrane
GO:0016310 IEA phosphorylation
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030296 IEA protein tyrosine kinase activator activity
GO:0040008 IEA regulation of growth
GO:0042802 IEA identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0046777 ISO protein autophosphorylation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 IEA negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018476 pak2b p21 (CDKN1A)-activated kinase 2b protein_coding Danio_rerio
ENSDARG00000068177 pak2a p21 (CDKN1A)-activated kinase 2a protein_coding Danio_rerio
ENSG00000180370 PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 protein_coding Homo_sapiens

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