C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: T-box 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000184058 TBX1 9606 + 22:19756703-19783593 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000329705 TBX1-002 19756703-19779546 protein_coding
  ENST00000332710 TBX1-003 19756703-19767334 protein_coding
  ENST00000359500 TBX1-001 19756703-19783593 protein_coding
  ENST00000475303 TBX1-004 19761197-19763702 retained_intron
  ENST00000484336 TBX1-005 19765079-19766327 retained_intron
  ENST00000621939 TBX1-201 19756703-19783022 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastLungMuscleOvaryTestisENST00000332710ENST00000621939
Transcript ID Adipose Adrenal Breast Lung Muscle Ovary Testis
ENST00000332710 3.177±0.00 31.283±0.00 3.818±0.00 3.973±0.00 64.878±59.22 3.495±0.00 12.797±0.00
ENST00000621939 N/A N/A N/A N/A 4.238±0.00 N/A 14.929±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008BW CIL_0008BW_0001 VISTA 22:19453681-20054184
CIL_00099J CIL_00099J_0001 VISTA 22:19461833-20062532
CIL_00095F CIL_00095F_0001 VISTA 22:19497462-20100487
CIL_0003KU CIL_0003KU_0002 CGP 22:19756703-19854939

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 ISS angiogenesis
GO:0001568 ISS blood vessel development
GO:0001708 ISS cell fate specification
GO:0001755 ISS neural crest cell migration
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001945 ISS lymph vessel development
GO:0001974 IEA blood vessel remodeling
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0003007 ISS heart morphogenesis
GO:0003148 ISS outflow tract septum morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003677 IDA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IDA:IEA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 ISS regulation of transcription from RNA polymerase II promoter
GO:0007368 ISS determination of left/right symmetry
GO:0007389 ISS pattern specification process
GO:0007498 ISS mesoderm development
GO:0007507 IMP heart development
GO:0007517 ISS muscle organ development
GO:0007605 ISS sensory perception of sound
GO:0008283 ISS cell proliferation
GO:0008284 ISS positive regulation of cell proliferation
GO:0009952 ISS anterior/posterior pattern specification
GO:0021644 ISS vagus nerve morphogenesis
GO:0030855 ISS epithelial cell differentiation
GO:0030878 ISS thyroid gland development
GO:0035176 ISS social behavior
GO:0035909 ISS aorta morphogenesis
GO:0042471 ISS ear morphogenesis
GO:0042472 ISS inner ear morphogenesis
GO:0042473 ISS outer ear morphogenesis
GO:0042474 ISS middle ear morphogenesis
GO:0042475 ISS odontogenesis of dentin-containing tooth
GO:0042693 ISS muscle cell fate commitment
GO:0042803 IDA protein homodimerization activity
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043565 IDA sequence-specific DNA binding
GO:0043587 ISS tongue morphogenesis
GO:0044344 ISS cellular response to fibroblast growth factor stimulus
GO:0045596 ISS negative regulation of cell differentiation
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046983 TAS protein dimerization activity
GO:0048384 ISS retinoic acid receptor signaling pathway
GO:0048514 ISS blood vessel morphogenesis
GO:0048538 IMP thymus development
GO:0048644 ISS muscle organ morphogenesis
GO:0048701 ISS embryonic cranial skeleton morphogenesis
GO:0048703 IMP embryonic viscerocranium morphogenesis
GO:0048752 ISS semicircular canal morphogenesis
GO:0048844 ISS artery morphogenesis
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0060017 IMP parathyroid gland development
GO:0060023 IMP soft palate development
GO:0060037 IMP pharyngeal system development
GO:0060325 ISS face morphogenesis
GO:0060415 ISS muscle tissue morphogenesis
GO:0060982 ISS coronary artery morphogenesis
GO:0070166 ISS enamel mineralization
GO:0071300 ISS cellular response to retinoic acid
GO:0071600 IEA otic vesicle morphogenesis
GO:0072513 IEA positive regulation of secondary heart field cardioblast proliferation
GO:0090103 ISS cochlea morphogenesis
GO:0097152 ISS mesenchymal cell apoptotic process
GO:2000027 ISS regulation of organ morphogenesis
GO:2001037 ISS positive regulation of tongue muscle cell differentiation
GO:2001054 ISS negative regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031891 tbx1 T-box 1 protein_coding Danio_rerio
ENSMUSG00000009097 Tbx1 T-box 1 protein_coding Mus_musculus

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