C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000185187 SIGIRR 9606 - 11:405716-417455 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000332725 SIGIRR-001 405716-417397 protein_coding
  ENST00000397632 SIGIRR-006 405716-417325 protein_coding
  ENST00000431843 SIGIRR-004 405716-414976 protein_coding
  ENST00000525070 SIGIRR-009 409466-414989 retained_intron
  ENST00000525299 SIGIRR-014 406876-414931 processed_transcript
  ENST00000526395 SIGIRR-023 405716-407135 protein_coding
  ENST00000526788 SIGIRR-013 407315-414923 processed_transcript
  ENST00000527136 SIGIRR-007 407897-414999 processed_transcript
  ENST00000527295 SIGIRR-003 405716-417455 retained_intron
  ENST00000527987 SIGIRR-020 405728-407191 retained_intron
  ENST00000528058 SIGIRR-008 408763-414996 protein_coding
  ENST00000528116 SIGIRR-012 407889-415004 processed_transcript
  ENST00000528209 SIGIRR-015 406843-414957 protein_coding
  ENST00000528536 SIGIRR-019 407233-407846 retained_intron
  ENST00000528698 SIGIRR-018 407063-410014 processed_transcript
  ENST00000528845 SIGIRR-021 405716-406370 protein_coding
  ENST00000529486 SIGIRR-010 407452-414989 processed_transcript
  ENST00000530494 SIGIRR-017 407452-414948 protein_coding
  ENST00000530683 SIGIRR-016 407527-410016 processed_transcript
  ENST00000531205 SIGIRR-002 405872-409977 protein_coding
  ENST00000534145 SIGIRR-022 406427-407195 retained_intron
  ENST00000534217 SIGIRR-011 407123-414984 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000397632ENST00000431843ENST00000525299ENST00000526395ENST00000527295ENST00000527987ENST00000528058ENST00000528698ENST00000528845ENST00000530494ENST00000531205ENST00000534145ENST00000534217
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000397632 N/A N/A 0.807±0.00 N/A 0.724±0.00 N/A N/A 7.944±0.00 N/A 0.067±0.00 N/A 3.533±2.43 N/A N/A
ENST00000431843 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.661±0.40 N/A
ENST00000525299 N/A N/A N/A N/A N/A 0.761±0.00 2.673±0.00 N/A 0.137±0.00 0.444±0.00 N/A N/A N/A N/A
ENST00000526395 9.804±0.00 N/A N/A 6.216±0.00 N/A 13.303±0.00 0.850±0.00 11.256±9.12 N/A N/A 0.929±0.00 16.363±7.05 N/A 4.495±3.48
ENST00000527295 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.099±0.00 N/A N/A N/A N/A
ENST00000527987 11.013±0.00 38.916±0.00 1.345±0.00 2.289±2.07 17.538±0.00 9.037±7.89 3.483±3.34 7.289±6.92 21.024±20.14 19.669±0.00 1.927±0.25 18.128±8.53 10.857±5.42 8.794±6.15
ENST00000528058 N/A N/A N/A N/A N/A N/A N/A 0.411±0.00 N/A N/A N/A N/A N/A N/A
ENST00000528698 N/A N/A N/A N/A N/A N/A N/A 0.378±0.00 N/A N/A N/A N/A 1.838±0.00 N/A
ENST00000528845 N/A N/A N/A N/A 0.919±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000530494 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.338±0.00 N/A N/A N/A N/A
ENST00000531205 N/A 11.371±0.00 0.409±0.00 0.165±0.00 1.119±0.89 2.872±0.00 N/A 6.198±0.00 N/A 4.502±0.00 N/A 5.913±0.00 N/A 1.830±0.00
ENST00000534145 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.539±0.00
ENST00000534217 N/A N/A N/A N/A 3.618±0.00 N/A N/A N/A N/A N/A N/A N/A 1.014±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002AQ CIL_0002AQ_0001 CGP 11:392614-417455
CIL_0002UO CIL_0002UO_0001 CGP 11:405716-442011

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001960 ISS negative regulation of cytokine-mediated signaling pathway
GO:0005515 IPI:IEA protein binding
GO:0006953 ISS acute-phase response
GO:0007165 IEA signal transduction
GO:0016020 IMP membrane
GO:0016021 IEA integral component of membrane
GO:0031665 TAS negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433 IMP negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079 ISS negative regulation of chemokine biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062204 sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain protein_coding Danio_rerio
ENSMUSG00000025494 Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain protein_coding Mus_musculus

Loading