C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: chemokine (C-X-C motif) receptor 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000186810 CXCR3 9606 - X:71615916-71618517 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000373691 CXCR3-001 71615916-71618510 protein_coding
  ENST00000373693 CXCR3-002 71615916-71618517 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000373691ENST00000373693
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000373691 N/A 0.859±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000373693 0.087±0.00 5.000±0.00 0.130±0.00 0.047±0.00 0.532±0.03 0.316±0.00 0.098±0.06 0.339±0.00 0.092±0.06 0.434±0.24 0.699±0.26 0.389±0.11 0.222±0.15

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00065Y CIL_00065Y_0001 CGP X:71615916-71718151

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001937 IDA negative regulation of endothelial cell proliferation
GO:0002685 IEA regulation of leukocyte migration
GO:0004872 IDA receptor activity
GO:0004930 IEA G-protein coupled receptor activity
GO:0004950 TAS chemokine receptor activity
GO:0005737 TAS cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006915 IEA apoptotic process
GO:0006928 TAS cellular component movement
GO:0006935 TAS chemotaxis
GO:0006954 IEA inflammatory response
GO:0007155 TAS cell adhesion
GO:0007166 IDA cell surface receptor signaling pathway
GO:0007186 IEA G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0008284 IDA positive regulation of cell proliferation
GO:0009897 IEA external side of plasma membrane
GO:0009986 IEA cell surface
GO:0010818 IEA T cell chemotaxis
GO:0016021 IEA integral component of membrane
GO:0016494 IEA C-X-C chemokine receptor activity
GO:0016525 IDA negative regulation of angiogenesis
GO:0019722 IEA calcium-mediated signaling
GO:0019956 IPI chemokine binding
GO:0019958 IDA C-X-C chemokine binding
GO:0030816 IDA positive regulation of cAMP metabolic process
GO:0043950 IDA positive regulation of cAMP-mediated signaling
GO:0045766 IDA positive regulation of angiogenesis
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0050921 IDA positive regulation of chemotaxis
GO:0051281 IMP positive regulation of release of sequestered calcium ion into cytosol
GO:0071954 IDA chemokine (C-C motif) ligand 11 production
GO:1900118 IDA negative regulation of execution phase of apoptosis
GO:1900119 IDA positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007358 cxcr3.1 chemokine (C-X-C motif) receptor 3, tandem duplicate 1 protein_coding Danio_rerio
ENSMUSG00000050232 Cxcr3 chemokine (C-X-C motif) receptor 3 protein_coding Mus_musculus

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