C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transmembrane protease, serine 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000187045 TMPRSS6 9606 - 22:37065436-37109563 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346753 TMPRSS6-003 37065436-37103656 protein_coding
  ENST00000381792 TMPRSS6-201 37065436-37103653 protein_coding
  ENST00000406725 TMPRSS6-001 37065439-37109409 protein_coding
  ENST00000406856 TMPRSS6-002 37065439-37109563 protein_coding
  ENST00000423761 TMPRSS6-005 37096070-37103518 protein_coding
  ENST00000429068 TMPRSS6-006 37082850-37084825 protein_coding
  ENST00000442782 TMPRSS6-004 37083940-37103656 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBreastColonHeartKidneyLiverOvaryPlacentaTestisENST00000346753ENST00000406725ENST00000406856ENST00000423761
Transcript ID Adrenal Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENST00000346753 N/A 0.025±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000406725 0.064±0.00 0.059±0.02 0.029±0.01 0.012±0.00 0.031±0.00 6.006±5.90 0.100±0.01 0.049±0.00 N/A
ENST00000406856 N/A N/A N/A N/A N/A N/A N/A 0.778±0.00 1.106±0.00
ENST00000423761 N/A N/A N/A N/A N/A N/A N/A 0.143±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00036O CIL_00036O_0001 CGP 22:37051736-37109563
CIL_00036P CIL_00036P_0001 CGP 22:37065436-37175054

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 NAS angiogenesis
GO:0003824 IEA catalytic activity
GO:0004252 IDA:IEA serine-type endopeptidase activity
GO:0005515 IPI:IEA protein binding
GO:0005886 IDA plasma membrane
GO:0006508 IDA:IEA proteolysis
GO:0016021 IDA integral component of membrane
GO:0030198 NAS extracellular matrix organization
GO:0030514 IEA negative regulation of BMP signaling pathway
GO:0035556 NAS intracellular signal transduction
GO:0042730 IDA fibrinolysis
GO:0055072 IMP iron ion homeostasis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000016942 Tmprss6 transmembrane serine protease 6 protein_coding Mus_musculus

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