C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mitogen-activated protein kinase 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000188130 MAPK12 9606 - 22:50245450-50261825 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000215659 MAPK12-001 50252903-50261825 protein_coding
  ENST00000395778 MAPK12-009 50257689-50261543 protein_coding
  ENST00000395780 MAPK12-004 50252903-50261308 protein_coding
  ENST00000467891 MAPK12-002 50252920-50261708 retained_intron
  ENST00000482969 MAPK12-005 50253788-50261231 retained_intron
  ENST00000488504 MAPK12-003 50252903-50261545 retained_intron
  ENST00000492218 MAPK12-010 50257563-50261169 processed_transcript
  ENST00000496942 MAPK12-007 50253781-50257107 retained_intron
  ENST00000497036 MAPK12-006 50245450-50261143 processed_transcript
  ENST00000497738 MAPK12-008 50253853-50256153 retained_intron
  ENST00000622558 MAPK12-201 50252903-50261716 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLungMuscleOvaryPlacentaTestisENST00000215659ENST00000395780ENST00000482969ENST00000488504ENST00000497036ENST00000622558
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Lung Muscle Ovary Placenta Testis
ENST00000215659 8.165±0.00 8.930±0.00 N/A 4.463±0.03 3.505±2.39 4.603±0.00 4.635±0.00 9.177±0.00 N/A 68.559±40.94 13.424±7.72 4.729±1.26 7.099±0.34
ENST00000395780 N/A 9.195±0.00 1.462±0.00 3.977±1.77 N/A N/A N/A 0.398±0.00 N/A 12.383±0.00 1.146±0.00 N/A N/A
ENST00000482969 N/A N/A N/A 1.434±0.00 0.564±0.00 N/A 0.462±0.00 N/A N/A N/A N/A N/A N/A
ENST00000488504 N/A N/A N/A N/A N/A N/A 0.809±0.00 N/A 0.781±0.00 N/A 15.137±0.00 N/A 4.008±0.00
ENST00000497036 N/A N/A 0.287±0.00 N/A 0.376±0.00 N/A N/A N/A 0.156±0.00 N/A 0.169±0.00 N/A N/A
ENST00000622558 N/A N/A N/A N/A N/A N/A N/A N/A 4.742±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000096 CIL_000096_0001 CGP 22:50217689-50251405
CIL_0006L4 CIL_0006L4_0001 CGP 22:50245183-50261825
CIL_00009B CIL_00009B_0001 CGP 22:50245450-50270767

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000287 IDA magnesium ion binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004707 IEA MAP kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006468 IEA protein phosphorylation
GO:0006975 TAS DNA damage induced protein phosphorylation
GO:0007050 TAS cell cycle arrest
GO:0007165 TAS signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007517 TAS muscle organ development
GO:0010952 NAS positive regulation of peptidase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0042692 TAS muscle cell differentiation
GO:0045445 IDA myoblast differentiation
GO:0045786 IEA negative regulation of cell cycle
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051149 TAS positive regulation of muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006409 mapk12b mitogen-activated protein kinase 12b protein_coding Danio_rerio
ENSDARG00000042021 mapk12a mitogen-activated protein kinase 12a protein_coding Danio_rerio
ENSMUSG00000022610 Mapk12 mitogen-activated protein kinase 12 protein_coding Mus_musculus

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