C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196136 SERPINA3 9606 + 14:94612384-94624055 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000393080 SERPINA3-007 94612384-94624055 protein_coding
  ENST00000467132 SERPINA3-002 94612391-94624054 protein_coding
  ENST00000482740 SERPINA3-003 94617642-94624052 protein_coding
  ENST00000485588 SERPINA3-004 94612384-94613857 processed_transcript
  ENST00000555820 SERPINA3-006 94612390-94619468 protein_coding
  ENST00000556388 SERPINA3-008 94612391-94622763 processed_transcript
  ENST00000556968 SERPINA3-009 94612405-94624054 nonsense_mediated_decay
  ENST00000621603 SERPINA3-010 94619333-94619971 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaENST00000393080ENST00000555820ENST00000556968
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta
ENST00000393080 6.146±0.00 26.403±0.00 84.368±0.00 8.356±0.00 30.122±0.00 15.112±0.00 393.863±0.00 4080.490±0.00 10.378±7.62 4.211±0.00 16.651±12.57 21.157±15.35
ENST00000555820 N/A N/A N/A 15.700±0.00 N/A 0.484±0.00 N/A N/A 1.868±0.00 0.646±0.00 N/A 2.156±0.00
ENST00000556968 N/A N/A N/A N/A 1.027±0.00 N/A N/A N/A N/A N/A 2.107±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000598 CIL_000598_000C CGP 14:94561442-94624646
CIL_000598 CIL_000598_000E CGP 14:94592058-94624646
CIL_0003QQ CIL_0003QQ_0001 CGP 14:94612384-94770230

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 TAS DNA binding
GO:0004867 IBA serine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 IBA extracellular region
GO:0005615 IEA:IDA extracellular space
GO:0005622 NAS intracellular
GO:0005634 TAS nucleus
GO:0006953 IEA acute-phase response
GO:0006954 NAS inflammatory response
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0019216 NAS regulation of lipid metabolic process
GO:0030162 IBA regulation of proteolysis
GO:0030277 NAS maintenance of gastrointestinal epithelium
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074712 si:ch211-186e20.2 si:ch211-186e20.2 protein_coding Danio_rerio
ENSDARG00000077960 si:ch211-186e20.7 si:ch211-186e20.7 protein_coding Danio_rerio
ENSDARG00000087143 serpina7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 protein_coding Danio_rerio
ENSDARG00000090286 serpina1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 protein_coding Danio_rerio
ENSDARG00000090850 serpina1l serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like protein_coding Danio_rerio
ENSDARG00000090916 CR559930.2 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000091136 zgc:174259 zgc:174259 protein_coding Danio_rerio
ENSDARG00000091800 zgc:174260 zgc:174260 protein_coding Danio_rerio
ENSMUSG00000021091 Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N protein_coding Mus_musculus
ENSMUSG00000041481 Serpina3g serine (or cysteine) peptidase inhibitor, clade A, member 3G protein_coding Mus_musculus
ENSMUSG00000041536 Serpina3a serine (or cysteine) peptidase inhibitor, clade A, member 3A protein_coding Mus_musculus
ENSMUSG00000058207 Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K protein_coding Mus_musculus
ENSMUSG00000066361 Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C protein_coding Mus_musculus
ENSMUSG00000066363 Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F protein_coding Mus_musculus
ENSMUSG00000066364 Serpina3b serine (or cysteine) peptidase inhibitor, clade A, member 3B protein_coding Mus_musculus
ENSMUSG00000079012 Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M protein_coding Mus_musculus
ENSMUSG00000079013 Serpina3j serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J protein_coding Mus_musculus
ENSMUSG00000079014 Serpina3i serine (or cysteine) peptidase inhibitor, clade A, member 3I protein_coding Mus_musculus

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