C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aldo-keto reductase family 1, member C3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196139 AKR1C3 9606 + 10:5035354-5107686 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380554 AKR1C3-001 5093793-5107686 protein_coding
  ENST00000439082 AKR1C3-201 5048766-5107680 protein_coding
  ENST00000470862 AKR1C3-002 5035357-5097533 processed_transcript
  ENST00000480697 AKR1C3-004 5094414-5098176 retained_intron
  ENST00000480822 AKR1C3-003 5035358-5097537 processed_transcript
  ENST00000602997 AKR1C3-008 5048789-5099414 protein_coding
  ENST00000603312 AKR1C3-009 5096145-5097528 retained_intron
  ENST00000603484 AKR1C3-010 5105275-5107686 retained_intron
  ENST00000605149 AKR1C3-006 5077638-5107680 protein_coding
  ENST00000605322 AKR1C3-005 5094418-5099893 retained_intron
  ENST00000605781 AKR1C3-007 5035354-5102210 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380554ENST00000439082ENST00000480697ENST00000605322ENST00000605781
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380554 N/A N/A 3.348±0.00 0.960±0.00 N/A N/A N/A N/A N/A N/A N/A 7.511±0.00 N/A N/A
ENST00000439082 80.306±0.00 12.845±0.00 3.962±0.00 1.981±0.86 97.721±93.29 32.163±8.51 3.254±1.82 118.416±0.00 145.748±0.00 15.234±10.52 3.878±0.41 17.602±7.55 1.730±0.52 9.421±7.51
ENST00000480697 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.186±0.00 N/A N/A
ENST00000605322 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.555±0.00 N/A
ENST00000605781 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.364±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002HN CIL_0002HN_0001 CGP 10:4922564-5135226
CIL_0002HN CIL_0002HN_0002 CGP 10:4963253-5107686
CIL_0002HN CIL_0002HN_0003 CGP 10:5035354-5218949

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IDA protein import into nucleus, translocation
GO:0001523 TAS retinoid metabolic process
GO:0001758 IDA retinal dehydrogenase activity
GO:0004032 IDA alditol:NADP+ 1-oxidoreductase activity
GO:0004033 TAS aldo-keto reductase (NADP) activity
GO:0004745 IDA retinol dehydrogenase activity
GO:0004958 IDA prostaglandin F receptor activity
GO:0005622 IDA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006693 IEP prostaglandin metabolic process
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007584 IEP response to nutrient
GO:0007603 TAS phototransduction, visible light
GO:0008202 IEP steroid metabolic process
GO:0008284 IDA positive regulation of cell proliferation
GO:0008584 IEP male gonad development
GO:0009267 IEP cellular response to starvation
GO:0010942 IDA positive regulation of cell death
GO:0016488 IDA farnesol catabolic process
GO:0016491 IEA oxidoreductase activity
GO:0016655 IDA oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0018636 IDA phenanthrene 9,10-monooxygenase activity
GO:0019369 TAS arachidonic acid metabolic process
GO:0019371 TAS cyclooxygenase pathway
GO:0030216 IEP keratinocyte differentiation
GO:0034614 IDA cellular response to reactive oxygen species
GO:0034694 IDA response to prostaglandin
GO:0035410 IDA dihydrotestosterone 17-beta-dehydrogenase activity
GO:0036131 IEA prostaglandin D2 11-ketoreductase activity
GO:0042448 IDA progesterone metabolic process
GO:0042574 IDA retinal metabolic process
GO:0044259 IEP multicellular organismal macromolecule metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044597 IMP daunorubicin metabolic process
GO:0044598 IMP doxorubicin metabolic process
GO:0045550 IDA geranylgeranyl reductase activity
GO:0045703 IDA ketoreductase activity
GO:0047017 IEA prostaglandin-F synthase activity
GO:0047020 IDA 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
GO:0047023 IDA androsterone dehydrogenase activity
GO:0047035 IEA testosterone dehydrogenase (NAD+) activity
GO:0047045 IEA testosterone 17-beta-dehydrogenase (NADP+) activity
GO:0047086 IDA ketosteroid monooxygenase activity
GO:0047115 IEA trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0047718 IEA indanol dehydrogenase activity
GO:0047787 IDA delta4-3-oxosteroid 5beta-reductase activity
GO:0048385 IDA regulation of retinoic acid receptor signaling pathway
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0055114 IDA oxidation-reduction process
GO:0061370 IMP testosterone biosynthetic process
GO:0070062 IDA extracellular vesicular exosome
GO:0070293 NAS renal absorption
GO:0071276 IDA cellular response to cadmium ion
GO:0071277 IDA cellular response to calcium ion
GO:0071379 IDA cellular response to prostaglandin stimulus
GO:0071384 IDA cellular response to corticosteroid stimulus
GO:0071395 IDA cellular response to jasmonic acid stimulus
GO:1900053 IDA negative regulation of retinoic acid biosynthetic process
GO:2000224 IMP regulation of testosterone biosynthetic process
GO:2000353 IDA positive regulation of endothelial cell apoptotic process
GO:2000379 IDA positive regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000021207 Akr1c21 aldo-keto reductase family 1, member C21 protein_coding Mus_musculus
ENSMUSG00000021210 Akr1c6 aldo-keto reductase family 1, member C6 protein_coding Mus_musculus
ENSMUSG00000021214 Akr1c18 aldo-keto reductase family 1, member C18 protein_coding Mus_musculus
ENSMUSG00000025955 Akr1cl aldo-keto reductase family 1, member C-like protein_coding Mus_musculus
ENSMUSG00000033715 Akr1c14 aldo-keto reductase family 1, member C14 protein_coding Mus_musculus
ENSMUSG00000054757 Akr1c20 aldo-keto reductase family 1, member C20 protein_coding Mus_musculus

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