C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: membrane metallo-endopeptidase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196549 MME 9606 + 3:155024124-155183729 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000360490 MME-006 155080399-155180488 protein_coding
  ENST00000382989 MME-003 155080021-155090500 protein_coding
  ENST00000460393 MME-001 155079647-155183708 protein_coding
  ENST00000462745 MME-004 155080094-155181584 protein_coding
  ENST00000462837 MME-012 155083944-155116708 protein_coding
  ENST00000473730 MME-010 155081344-155115077 protein_coding
  ENST00000477669 MME-013 155112294-155115147 processed_transcript
  ENST00000481828 MME-008 155079856-155118791 protein_coding
  ENST00000491026 MME-009 155080964-155115155 protein_coding
  ENST00000491597 MME-002 155079647-155085729 retained_intron
  ENST00000492661 MME-007 155024124-155180849 protein_coding
  ENST00000493237 MME-005 155080111-155180628 protein_coding
  ENST00000493888 MME-014 155172104-155180738 retained_intron
  ENST00000495577 MME-015 155160390-155168883 retained_intron
  ENST00000497890 MME-011 155083525-155084213 protein_coding
  ENST00000615825 MME-201 155084168-155183729 protein_coding
  ENST00000616757 MME-202 155080021-155090499 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000360490ENST00000460393ENST00000462745ENST00000491597ENST00000493237ENST00000493888ENST00000495577ENST00000615825
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000360490 N/A N/A N/A 0.052±0.00 2.072±0.00 1.969±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000460393 7.005±0.00 N/A N/A 0.011±0.00 8.508±7.42 N/A 0.097±0.00 13.043±0.00 0.523±0.00 5.616±0.88 N/A N/A N/A N/A
ENST00000462745 N/A N/A N/A N/A N/A N/A 0.134±0.00 1.430±0.00 0.934±0.00 N/A N/A 0.337±0.00 N/A N/A
ENST00000491597 N/A N/A N/A 0.109±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000493237 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.837±0.00 N/A N/A N/A
ENST00000493888 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.706±0.00 N/A N/A N/A
ENST00000495577 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.645±0.00 N/A N/A
ENST00000615825 3.455±0.00 0.377±0.00 5.099±0.00 0.088±0.04 7.651±0.00 0.974±0.00 0.362±0.06 9.138±7.82 2.065±0.00 2.912±0.24 1.729±1.45 0.322±0.10 8.606±4.51 0.569±0.21

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000669 CIL_000669_0001 CGP 3:154337672-155183729
CIL_000291 CIL_000291_0001 CGP 3:155024124-155745067

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001822 IEP kidney development
GO:0002003 TAS angiotensin maturation
GO:0004175 IDA endopeptidase activity
GO:0004222 IEA:IMP metalloendopeptidase activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005903 IDA brush border
GO:0005925 IDA focal adhesion
GO:0006508 IDA:IEA proteolysis
GO:0006518 ISS peptide metabolic process
GO:0008021 ISS synaptic vesicle
GO:0008233 IEA peptidase activity
GO:0008270 IDA zinc ion binding
GO:0016020 IEA membrane
GO:0016021 NAS integral component of membrane
GO:0019233 ISS sensory perception of pain
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0042277 ISS peptide binding
GO:0044267 TAS cellular protein metabolic process
GO:0044306 ISS neuron projection terminus
GO:0045202 ISS synapse
GO:0046449 IMP creatinine metabolic process
GO:0050435 ISS beta-amyloid metabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:0071345 IDA cellular response to cytokine stimulus
GO:0071492 IDA cellular response to UV-A
GO:0071493 IDA cellular response to UV-B
GO:0090399 IEP replicative senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000027820 Mme membrane metallo endopeptidase protein_coding Mus_musculus

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