C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000197249 SERPINA1 9606 - 14:94376747-94390693 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355814 SERPINA1-201 94376747-94390692 protein_coding
  ENST00000393087 SERPINA1-004 94378349-94388820 protein_coding
  ENST00000393088 SERPINA1-002 94378376-94390693 protein_coding
  ENST00000402629 SERPINA1-006 94379113-94388589 protein_coding
  ENST00000404814 SERPINA1-003 94378389-94390662 protein_coding
  ENST00000437397 SERPINA1-202 94376747-94390692 protein_coding
  ENST00000440909 SERPINA1-001 94376747-94390637 protein_coding
  ENST00000448921 SERPINA1-203 94376747-94390692 protein_coding
  ENST00000449399 SERPINA1-008 94378449-94390650 protein_coding
  ENST00000489769 SERPINA1-005 94378373-94383246 nonsense_mediated_decay
  ENST00000553327 SERPINA1-015 94382960-94390614 protein_coding
  ENST00000554720 SERPINA1-016 94382663-94388665 protein_coding
  ENST00000555289 SERPINA1-014 94383629-94390635 processed_transcript
  ENST00000556091 SERPINA1-017 94382769-94388591 protein_coding
  ENST00000556955 SERPINA1-011 94382887-94390635 protein_coding
  ENST00000557093 SERPINA1-012 94389557-94390635 processed_transcript
  ENST00000557118 SERPINA1-010 94383171-94390635 protein_coding
  ENST00000557361 SERPINA1-013 94388610-94390635 retained_intron
  ENST00000557492 SERPINA1-007 94382804-94390676 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000393087ENST00000393088ENST00000404814ENST00000440909ENST00000448921ENST00000449399ENST00000553327ENST00000554720ENST00000557492
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000393087 N/A 3.900±0.00 17.171±0.00 1.225±0.00 15.976±6.76 3.550±0.00 1.514±1.20 1312.975±202.91 N/A 122.834±98.45 N/A 4.806±2.42 13.651±8.02 17.736±0.00
ENST00000393088 N/A 3.960±0.00 N/A N/A N/A 1.415±0.00 N/A N/A N/A N/A 0.775±0.00 0.916±0.41 0.933±0.00 N/A
ENST00000404814 23.654±0.00 11.850±0.00 N/A 5.184±0.00 8.896±0.00 3.839±1.28 0.797±0.59 N/A N/A 73.121±0.00 0.230±0.00 3.691±1.42 11.669±7.15 13.355±13.15
ENST00000440909 N/A N/A N/A 0.186±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000448921 N/A N/A N/A N/A N/A N/A N/A N/A 0.205±0.00 N/A N/A N/A N/A N/A
ENST00000449399 N/A N/A 5.819±0.00 1.774±0.75 7.420±0.00 2.729±0.00 0.941±0.00 N/A 1.632±0.00 70.226±0.00 0.619±0.00 1.357±0.00 3.233±0.00 N/A
ENST00000553327 N/A N/A N/A N/A N/A N/A N/A 1619.070±0.00 N/A N/A N/A 1.884±0.00 N/A N/A
ENST00000554720 N/A N/A N/A N/A N/A N/A 0.856±0.00 N/A 2.124±0.00 N/A N/A N/A N/A N/A
ENST00000557492 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.949±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000598 CIL_000598_000A CGP 14:94304248-94390693
CIL_000598 CIL_000598_000D CGP 14:94376747-94452790

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IEA response to hypoxia
GO:0001948 IPI glycoprotein binding
GO:0002020 IPI protease binding
GO:0002576 TAS platelet degranulation
GO:0004866 IEA endopeptidase inhibitor activity
GO:0004867 NAS serine-type endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0005576 NAS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 IEA:IMP extracellular space
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0006953 IEA acute-phase response
GO:0006954 IEA inflammatory response
GO:0007596 TAS blood coagulation
GO:0010035 IEA response to inorganic substance
GO:0010288 IEA response to lead ion
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0014070 IEA response to organic cyclic compound
GO:0030162 IBA regulation of proteolysis
GO:0030168 TAS platelet activation
GO:0031093 TAS platelet alpha granule lumen
GO:0032355 IEA response to estradiol
GO:0032496 IEA response to lipopolysaccharide
GO:0033986 IEA response to methanol
GO:0034014 IEA response to triglyceride
GO:0034097 IEA response to cytokine
GO:0042802 IPI identical protein binding
GO:0046687 IEA response to chromate
GO:0070062 IDA extracellular vesicular exosome
GO:1900004 IEA negative regulation of serine-type endopeptidase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074712 si:ch211-186e20.2 si:ch211-186e20.2 protein_coding Danio_rerio
ENSDARG00000077960 si:ch211-186e20.7 si:ch211-186e20.7 protein_coding Danio_rerio
ENSDARG00000087143 serpina7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 protein_coding Danio_rerio
ENSDARG00000090286 serpina1 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 protein_coding Danio_rerio
ENSDARG00000090850 serpina1l serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like protein_coding Danio_rerio
ENSDARG00000090916 CR559930.2 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000091136 zgc:174259 zgc:174259 protein_coding Danio_rerio
ENSDARG00000091800 zgc:174260 zgc:174260 protein_coding Danio_rerio
ENSMUSG00000066366 Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A protein_coding Mus_musculus
ENSMUSG00000071177 Serpina1d serine (or cysteine) peptidase inhibitor, clade A, member 1D protein_coding Mus_musculus
ENSMUSG00000071178 Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B protein_coding Mus_musculus
ENSMUSG00000072849 Serpina1e serine (or cysteine) peptidase inhibitor, clade A, member 1E protein_coding Mus_musculus
ENSMUSG00000079015 Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C protein_coding Mus_musculus

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