C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: G protein-coupled receptor kinase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198055 GRK6 9606 + 5:177403204-177442901 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355472 GRK6-001 177426678-177442830 protein_coding
  ENST00000355958 GRK6-004 177426843-177441353 protein_coding
  ENST00000393576 GRK6-011 177426794-177442901 protein_coding
  ENST00000502598 GRK6-009 177403204-177432257 protein_coding
  ENST00000506296 GRK6-008 177404406-177434030 protein_coding
  ENST00000507633 GRK6-003 177426745-177436685 protein_coding
  ENST00000508705 GRK6-007 177432233-177436121 nonsense_mediated_decay
  ENST00000511244 GRK6-005 177426496-177433189 protein_coding
  ENST00000512684 GRK6-006 177426854-177430967 protein_coding
  ENST00000515666 GRK6-002 177431711-177442064 retained_intron
  ENST00000528793 GRK6-010 177426843-177442625 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355472ENST00000355958ENST00000393576ENST00000502598ENST00000506296ENST00000507633ENST00000508705ENST00000515666ENST00000528793
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355472 N/A 7.700±0.00 N/A 3.351±0.00 3.004±0.00 3.485±0.00 0.844±0.52 1.715±0.00 N/A N/A 1.085±0.31 3.667±0.92 2.469±0.36 4.634±1.46
ENST00000355958 N/A N/A 0.887±0.00 2.609±0.00 N/A N/A 0.882±0.81 N/A N/A N/A 1.666±0.00 N/A N/A N/A
ENST00000393576 N/A N/A N/A N/A 0.684±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000502598 N/A N/A 1.910±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000506296 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.823±0.00 N/A N/A
ENST00000507633 N/A N/A N/A N/A 1.090±0.00 N/A N/A N/A N/A 3.717±0.00 0.304±0.00 N/A N/A N/A
ENST00000508705 N/A N/A N/A 5.936±0.00 N/A N/A N/A N/A N/A N/A 3.801±0.00 7.767±0.00 5.769±0.00 11.314±0.00
ENST00000515666 2.880±0.00 N/A N/A 2.572±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.500±0.00
ENST00000528793 6.583±0.00 32.599±0.00 N/A 1.936±0.62 3.413±2.80 6.016±0.00 2.237±0.00 5.553±0.00 0.377±0.00 5.434±3.78 4.233±0.00 8.374±1.44 7.056±2.55 4.266±0.05

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A2 CIL_0008A2_0001 VISTA 5:177089375-177692188
CIL_0002YG CIL_0002YG_0001 CGP 5:177400107-177409576
CIL_0002YH CIL_0002YH_0001 CGP 5:177402140-177442901
CIL_0000XA CIL_0000XA_0002 CGP 5:177403204-177456286

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004703 IEA G-protein coupled receptor kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0008277 TAS:IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0016020 IDA membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032157 GRK6 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000074886 Grk6 G protein-coupled receptor kinase 6 protein_coding Mus_musculus

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