C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurotrophic tyrosine kinase, receptor, type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198400 NTRK1 9606 + 1:156815640-156881850 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000358660 NTRK1-006 156860894-156881711 protein_coding
  ENST00000368196 NTRK1-001 156860815-156881850 protein_coding
  ENST00000392302 NTRK1-004 156815656-156881794 protein_coding
  ENST00000489021 NTRK1-008 156815640-156873890 processed_transcript
  ENST00000497019 NTRK1-002 156815679-156881849 nonsense_mediated_decay
  ENST00000524377 NTRK1-007 156860894-156881642 protein_coding
  ENST00000530298 NTRK1-005 156837209-156881850 retained_intron
  ENST00000531606 NTRK1-011 156880001-156881850 processed_transcript
  ENST00000533630 NTRK1-009 156860913-156865063 retained_intron
  ENST00000534682 NTRK1-010 156874153-156876199 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonLiverLungMuscleOvaryPlacentaTestisENST00000358660ENST00000368196ENST00000392302ENST00000489021ENST00000497019ENST00000524377ENST00000530298ENST00000531606ENST00000534682
Transcript ID Adipose Bladder Brain Breast Colon Liver Lung Muscle Ovary Placenta Testis
ENST00000358660 N/A N/A N/A N/A N/A N/A N/A N/A 0.108±0.00 N/A N/A
ENST00000368196 N/A N/A N/A N/A 0.394±0.00 N/A N/A N/A 0.188±0.00 0.076±0.00 N/A
ENST00000392302 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.169±0.06 N/A
ENST00000489021 N/A N/A N/A N/A N/A N/A N/A N/A 0.531±0.00 0.787±0.56 N/A
ENST00000497019 0.104±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.708±0.00
ENST00000524377 N/A 0.182±0.00 0.147±0.00 N/A N/A 0.012±0.00 0.434±0.00 0.031±0.00 0.032±0.00 0.385±0.00 N/A
ENST00000530298 N/A N/A N/A 0.025±0.00 N/A N/A N/A N/A 0.064±0.00 0.064±0.00 N/A
ENST00000531606 N/A N/A N/A 0.219±0.00 N/A N/A N/A 0.119±0.00 N/A N/A N/A
ENST00000534682 0.137±0.00 N/A N/A N/A N/A 0.099±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000850 CIL_000850_0001 VISTA 1:156360457-156965492
CIL_0005I5 CIL_0005I5_0001 CGP 1:156815640-156881850

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 TAS activation of MAPKK activity
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IEA transmembrane receptor protein tyrosine kinase activity
GO:0005030 IEA neurotrophin receptor activity
GO:0005166 IEA neurotrophin p75 receptor binding
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 TAS endosome
GO:0005769 ISS early endosome
GO:0005770 ISS late endosome
GO:0005886 ISS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007169 IEA transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 TAS activation of adenylate cyclase activity
GO:0007202 TAS activation of phospholipase C activity
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007399 IEA nervous system development
GO:0007411 IEA axon guidance
GO:0007568 IEA aging
GO:0007611 IEA learning or memory
GO:0007623 IEA circadian rhythm
GO:0008285 IDA negative regulation of cell proliferation
GO:0009314 IEA response to radiation
GO:0009986 IEA cell surface
GO:0010465 IDA nerve growth factor receptor activity
GO:0010623 ISS developmental programmed cell death
GO:0010976 IDA positive regulation of neuron projection development
GO:0014823 IEA response to activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0021553 IEA olfactory nerve development
GO:0030183 IEA B cell differentiation
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0031667 IEA response to nutrient levels
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0035094 IEA response to nicotine
GO:0038179 IEA neurotrophin signaling pathway
GO:0038180 IEA nerve growth factor signaling pathway
GO:0042490 IEA mechanoreceptor differentiation
GO:0042493 IEA response to drug
GO:0042803 IDA protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043068 ISS positive regulation of programmed cell death
GO:0043121 TAS neurotrophin binding
GO:0043234 ISS protein complex
GO:0043235 IDA receptor complex
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0045471 IEA response to ethanol
GO:0045766 IDA positive regulation of angiogenesis
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0046777 IDA protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048011 IDA neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048406 IDA nerve growth factor binding
GO:0048485 ISS sympathetic nervous system development
GO:0048678 IEA response to axon injury
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051599 IEA response to hydrostatic pressure
GO:0051602 IEA response to electrical stimulus
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060009 IEA Sertoli cell development
GO:0060385 ISS axonogenesis involved in innervation
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071316 IEA cellular response to nicotine
GO:0071363 IEA cellular response to growth factor stimulus
GO:1901215 IEA negative regulation of neuron death
GO:1990090 ISS cellular response to nerve growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004586 ntrk1 neurotrophic tyrosine kinase, receptor, type 1 protein_coding Danio_rerio
ENSMUSG00000028072 Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 protein_coding Mus_musculus

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