C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neurotrophic tyrosine kinase, receptor, type 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000524377 NTRK1-007 ENSG00000198400 9606 + 1:156860894-156881642 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainLiverLungMuscleOvaryPlacentaENST00000524377
Transcript ID Bladder Brain Liver Lung Muscle Ovary Placenta
ENST00000524377 0.182±0.00 0.147±0.00 0.012±0.00 0.434±0.00 0.031±0.00 0.032±0.00 0.385±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000850 CIL_000850_0001 VISTA 1:156360457-156965492
CIL_0005I5 CIL_0005I5_0001 CGP 1:156815640-156881850

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000186 TAS activation of MAPKK activity
GO:0004672 IEA protein kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004714 IDA transmembrane receptor protein tyrosine kinase activity
GO:0005166 IEA neurotrophin p75 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005768 TAS endosome
GO:0005769 ISS early endosome
GO:0005770 ISS late endosome
GO:0005886 ISS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 TAS activation of adenylate cyclase activity
GO:0007202 TAS activation of phospholipase C activity
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007399 IEA nervous system development
GO:0007411 IEA axon guidance
GO:0007568 IEA aging
GO:0007611 IEA learning or memory
GO:0007623 IEA circadian rhythm
GO:0008285 IDA negative regulation of cell proliferation
GO:0009314 IEA response to radiation
GO:0009986 IEA cell surface
GO:0010465 IDA nerve growth factor receptor activity
GO:0010623 ISS developmental programmed cell death
GO:0010976 IDA positive regulation of neuron projection development
GO:0014823 IEA response to activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019233 IEA sensory perception of pain
GO:0021553 IEA olfactory nerve development
GO:0030183 IEA B cell differentiation
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0031410 IEA cytoplasmic vesicle
GO:0031667 IEA response to nutrient levels
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0035094 IEA response to nicotine
GO:0038180 IEA nerve growth factor signaling pathway
GO:0042490 IEA mechanoreceptor differentiation
GO:0042493 IEA response to drug
GO:0042803 IDA protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043068 ISS positive regulation of programmed cell death
GO:0043121 TAS neurotrophin binding
GO:0043234 ISS protein complex
GO:0043235 IDA receptor complex
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0045471 IEA response to ethanol
GO:0045766 IDA positive regulation of angiogenesis
GO:0046579 IDA positive regulation of Ras protein signal transduction
GO:0046777 IDA protein autophosphorylation
GO:0046875 IEA ephrin receptor binding
GO:0048011 IDA neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048406 IDA nerve growth factor binding
GO:0048485 ISS sympathetic nervous system development
GO:0048678 IEA response to axon injury
GO:0050965 IEA detection of temperature stimulus involved in sensory perception of pain
GO:0050966 IEA detection of mechanical stimulus involved in sensory perception of pain
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0051599 IEA response to hydrostatic pressure
GO:0051602 IEA response to electrical stimulus
GO:0051968 IEA positive regulation of synaptic transmission, glutamatergic
GO:0060009 IEA Sertoli cell development
GO:0060385 ISS axonogenesis involved in innervation
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071316 IEA cellular response to nicotine
GO:0071363 IEA cellular response to growth factor stimulus
GO:1901215 IEA negative regulation of neuron death
GO:1990090 ISS cellular response to nerve growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029712 Ntrk1-201 protein_coding Mus_musculus 0 2499
ENSMUST00000079828 Ntrk2-201 protein_coding Mus_musculus 0 396

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