C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mechanistic target of rapamycin (serine/threonine kinase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198793 MTOR 9606 - 1:11106535-11262507 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361445 MTOR-001 11106535-11262507 protein_coding
  ENST00000376838 MTOR-002 11106535-11131558 protein_coding
  ENST00000455339 MTOR-005 11109303-11115663 protein_coding
  ENST00000473471 MTOR-007 11107285-11114629 processed_transcript
  ENST00000476768 MTOR-004 11138954-11139660 processed_transcript
  ENST00000490931 MTOR-006 11107307-11115527 processed_transcript
  ENST00000495435 MTOR-003 11131594-11145025 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361445ENST00000376838
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361445 5.052±0.00 3.381±0.00 1.787±0.00 5.867±0.02 3.704±0.21 3.849±0.77 5.280±2.75 4.624±0.50 2.380±0.44 2.477±0.90 10.351±7.57 4.631±1.63 3.189±0.32 17.909±2.63
ENST00000376838 3.466±0.00 3.828±0.00 N/A 3.541±0.00 2.383±0.00 1.107±0.00 N/A N/A 2.820±0.00 0.828±0.00 4.176±1.63 3.655±0.96 1.790±0.59 11.189±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JG CIL_0008JG_0001 VISTA 1:10565145-11165671
CIL_0008JY CIL_0008JY_0001 VISTA 1:10605072-11206087
CIL_00019S CIL_00019S_0002 CGP 1:11106535-11262507

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001030 IDA RNA polymerase III type 1 promoter DNA binding
GO:0001031 IDA RNA polymerase III type 2 promoter DNA binding
GO:0001032 IDA RNA polymerase III type 3 promoter DNA binding
GO:0001156 IDA TFIIIC-class transcription factor binding
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005764 IDA lysosome
GO:0005765 IDA lysosomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005942 NAS phosphatidylinositol 3-kinase complex
GO:0005979 IEA regulation of glycogen biosynthetic process
GO:0006109 IEA regulation of carbohydrate metabolic process
GO:0006468 IDA protein phosphorylation
GO:0006950 IMP response to stress
GO:0007165 NAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007281 IEA germ cell development
GO:0007584 NAS response to nutrient
GO:0008144 IEA drug binding
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010507 ISS negative regulation of autophagy
GO:0010592 IEA positive regulation of lamellipodium assembly
GO:0010628 IMP positive regulation of gene expression
GO:0010831 IEA positive regulation of myotube differentiation
GO:0012505 IDA endomembrane system
GO:0016020 IDA membrane
GO:0016049 TAS cell growth
GO:0016242 IEA negative regulation of macroautophagy
GO:0016301 TAS kinase activity
GO:0016310 IDA phosphorylation
GO:0016605 ISS PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IMP peptidyl-serine phosphorylation
GO:0018107 IEA peptidyl-threonine phosphorylation
GO:0019904 IEA protein domain specific binding
GO:0030030 IEA cell projection organization
GO:0030163 TAS protein catabolic process
GO:0030425 IEA dendrite
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0031295 TAS T cell costimulation
GO:0031529 IEA ruffle organization
GO:0031641 IEA regulation of myelination
GO:0031669 ISS cellular response to nutrient levels
GO:0031929 IMP TOR signaling
GO:0031931 IDA TORC1 complex
GO:0031932 IDA TORC2 complex
GO:0031998 IEA regulation of fatty acid beta-oxidation
GO:0032095 IEA regulation of response to food
GO:0032314 IEA regulation of Rac GTPase activity
GO:0032868 IEA response to insulin
GO:0032956 IMP regulation of actin cytoskeleton organization
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0040007 NAS growth
GO:0043022 IEA ribosome binding
GO:0043025 IEA neuronal cell body
GO:0043200 IDA response to amino acid
GO:0043610 IEA regulation of carbohydrate utilization
GO:0045087 TAS innate immune response
GO:0045727 IDA positive regulation of translation
GO:0045792 IEA negative regulation of cell size
GO:0045859 IEA regulation of protein kinase activity
GO:0045945 IMP positive regulation of transcription from RNA polymerase III promoter
GO:0046777 IDA protein autophosphorylation
GO:0046889 IMP positive regulation of lipid biosynthetic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0051219 IPI phosphoprotein binding
GO:0051496 IEA positive regulation of stress fiber assembly
GO:0051534 IEA negative regulation of NFAT protein import into nucleus
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070438 IEA mTOR-FKBP12-rapamycin complex
GO:0071456 ISS cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053196 mtor mechanistic target of rapamycin (serine/threonine kinase) protein_coding Danio_rerio
ENSMUSG00000028991 Mtor mechanistic target of rapamycin (serine/threonine kinase) protein_coding Mus_musculus

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