C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: mechanistic target of rapamycin (serine/threonine kinase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028991 Mtor 10090 + 4:148448611-148557683 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000057580 Mtor-002 148448625-148454973 protein_coding
  ENSMUST00000103221 Mtor-001 148448611-148557683 protein_coding
  ENSMUST00000123566 Mtor-003 148448611-148454969 retained_intron
  ENSMUST00000129715 Mtor-004 148544413-148547788 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000103221
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000103221 9.692±1.31 9.997±1.50 4.707±0.85 13.471±3.76 7.878±1.00 5.798±0.71 5.611±0.52 14.493±1.87 4.105±0.87 7.102±0.84 4.860±0.27 10.014±1.31 9.724±4.70 23.659±1.71

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008JY CIL_0008JY_0002 VISTA 4:148408124-149009196
CIL_0008JG CIL_0008JG_0002 VISTA 4:148444314-149044861
CIL_00019S CIL_00019S_0003 CGP 4:148448611-148557683

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001030 IEA RNA polymerase III type 1 promoter DNA binding
GO:0001031 IEA RNA polymerase III type 2 promoter DNA binding
GO:0001032 IEA RNA polymerase III type 3 promoter DNA binding
GO:0001156 IEA TFIIIC-class transcription factor binding
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 ISS cytoplasm
GO:0005741 IEA mitochondrial outer membrane
GO:0005764 ISS lysosome
GO:0005765 IEA lysosomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005829 IDA cytosol
GO:0005979 IEA regulation of glycogen biosynthetic process
GO:0006109 IEA regulation of carbohydrate metabolic process
GO:0006468 ISO protein phosphorylation
GO:0006950 IEA response to stress
GO:0007281 IDA germ cell development
GO:0008144 IEA drug binding
GO:0010507 IMP negative regulation of autophagy
GO:0010592 IDA positive regulation of lamellipodium assembly
GO:0010628 IEA positive regulation of gene expression
GO:0010831 IGI positive regulation of myotube differentiation
GO:0012505 IEA endomembrane system
GO:0016020 IEA membrane
GO:0016242 IMP negative regulation of macroautophagy
GO:0016301 ISO kinase activity
GO:0016310 IEA phosphorylation
GO:0016605 IDA PML body
GO:0018105 IMP peptidyl-serine phosphorylation
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019904 IEA protein domain specific binding
GO:0030030 IMP cell projection organization
GO:0030425 IDA dendrite
GO:0030838 IDA positive regulation of actin filament polymerization
GO:0031529 IDA ruffle organization
GO:0031641 IMP regulation of myelination
GO:0031669 IDA cellular response to nutrient levels
GO:0031929 IEA TOR signaling
GO:0031931 ISO TORC1 complex
GO:0031932 ISO TORC2 complex
GO:0031998 IEA regulation of fatty acid beta-oxidation
GO:0032095 IEA regulation of response to food
GO:0032314 IMP regulation of Rac GTPase activity
GO:0032868 IDA response to insulin
GO:0032956 IEA regulation of actin cytoskeleton organization
GO:0043022 IDA ribosome binding
GO:0043025 IEA neuronal cell body
GO:0043200 IDA response to amino acid
GO:0043610 IEA regulation of carbohydrate utilization
GO:0045727 IEA positive regulation of translation
GO:0045792 IGI negative regulation of cell size
GO:0045859 IGI regulation of protein kinase activity
GO:0045945 IEA positive regulation of transcription from RNA polymerase III promoter
GO:0046777 ISO protein autophosphorylation
GO:0046889 ISS positive regulation of lipid biosynthetic process
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0051219 IEA phosphoprotein binding
GO:0051496 IDA positive regulation of stress fiber assembly
GO:0051534 IMP negative regulation of NFAT protein import into nucleus
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070438 IEA mTOR-FKBP12-rapamycin complex
GO:0071456 IDA cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053196 mtor mechanistic target of rapamycin (serine/threonine kinase) protein_coding Danio_rerio
ENSG00000198793 MTOR mechanistic target of rapamycin (serine/threonine kinase) protein_coding Homo_sapiens

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