C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD3e molecule, epsilon (CD3-TCR complex)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000198851 CD3E 9606 + 11:118304545-118316175 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361763 CD3E-001 118304545-118316175 protein_coding
  ENST00000526146 CD3E-004 118304737-118316175 retained_intron
  ENST00000528435 CD3E-002 118304730-118313744 retained_intron
  ENST00000528600 CD3E-007 118304899-118316171 protein_coding
  ENST00000529713 CD3E-003 118304730-118313341 retained_intron
  ENST00000531913 CD3E-009 118312144-118315986 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000361763ENST00000528435ENST00000528600ENST00000531913
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000361763 0.862±0.00 10.302±0.00 0.244±0.00 N/A 1.318±0.00 N/A 0.076±0.00 0.517±0.00 0.447±0.00 3.641±1.56 1.267±0.27 1.342±0.33 0.168±0.00
ENST00000528435 N/A N/A N/A N/A N/A N/A N/A N/A 0.722±0.00 1.658±0.00 N/A N/A N/A
ENST00000528600 N/A 48.965±0.00 N/A 0.275±0.00 1.684±0.00 3.175±0.00 0.347±0.04 1.269±0.00 1.287±0.00 8.364±7.35 2.358±0.22 1.229±0.30 1.962±0.00
ENST00000531913 N/A N/A 0.127±0.00 N/A N/A 2.276±0.00 N/A N/A 1.157±0.00 N/A N/A N/A 0.420±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081E CIL_00081E_0001 VISTA 11:118137591-118740525

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IEA immunological synapse
GO:0002669 IEA positive regulation of T cell anergy
GO:0004871 IEA signal transducer activity
GO:0004888 NAS:IEA transmembrane signaling receptor activity
GO:0005057 TAS receptor signaling protein activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006461 NAS protein complex assembly
GO:0007166 NAS:IEA cell surface receptor signaling pathway
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 TAS signal complex assembly
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007584 IEA response to nutrient
GO:0009897 IDA external side of plasma membrane
GO:0016020 IEA membrane
GO:0017124 IPI SH3 domain binding
GO:0019901 NAS protein kinase binding
GO:0030159 NAS receptor signaling complex scaffold activity
GO:0031295 TAS T cell costimulation
GO:0032729 IEA positive regulation of interferon-gamma production
GO:0032753 IEA positive regulation of interleukin-4 production
GO:0033077 IEA T cell differentiation in thymus
GO:0035556 TAS intracellular signal transduction
GO:0042101 IDA T cell receptor complex
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042105 IEA alpha-beta T cell receptor complex
GO:0042110 NAS T cell activation
GO:0042608 NAS T cell receptor binding
GO:0042981 NAS regulation of apoptotic process
GO:0045060 IEA negative thymic T cell selection
GO:0045086 IEA positive regulation of interleukin-2 biosynthetic process
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0046641 IEA positive regulation of alpha-beta T cell proliferation
GO:0046649 IEA lymphocyte activation
GO:0046982 IPI protein heterodimerization activity
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 TAS regulation of immune response
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050852 TAS T cell receptor signaling pathway
GO:0050870 IEA positive regulation of T cell activation
GO:0097190 IEA apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000032093 Cd3e CD3 antigen, epsilon polypeptide protein_coding Mus_musculus

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