C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: allograft inflammatory factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000204472 AIF1 9606 + 6:31615184-31617021 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337917 AIF1-004 31615227-31617021 protein_coding
  ENST00000376049 AIF1-002 31615991-31617021 protein_coding
  ENST00000376059 AIF1-001 31615184-31617021 protein_coding
  ENST00000466820 AIF1-006 31615280-31617021 retained_intron
  ENST00000497362 AIF1-003 31615217-31616340 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337917ENST00000376049ENST00000376059ENST00000466820
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337917 10.627±0.00 34.820±0.00 N/A 7.139±5.69 9.168±0.48 6.065±2.59 3.223±2.53 7.862±5.31 2.361±0.13 16.124±8.08 0.655±0.14 5.153±3.85 29.105±14.73 5.683±5.29
ENST00000376049 N/A 20.216±0.00 3.202±0.00 6.323±1.24 N/A N/A 1.363±0.35 6.438±0.00 3.355±1.66 4.791±1.55 0.413±0.00 2.405±1.56 4.055±0.00 2.239±1.87
ENST00000376059 14.975±0.00 31.978±0.00 0.846±0.00 5.044±2.68 6.978±3.20 3.013±1.51 3.140±2.19 3.518±2.66 3.726±2.64 9.954±5.41 N/A 6.511±5.40 47.518±29.79 3.775±3.69
ENST00000466820 N/A N/A N/A N/A N/A N/A N/A N/A 0.569±0.00 N/A N/A N/A N/A 0.074±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IEA ruffle
GO:0001774 NAS microglial cell activation
GO:0001891 ISS phagocytic cup
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0003674 ND molecular_function
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 IDA cytosol
GO:0005884 IDA actin filament
GO:0006911 ISS phagocytosis, engulfment
GO:0006954 ISS inflammatory response
GO:0010629 IEA negative regulation of gene expression
GO:0014739 IEA positive regulation of muscle hyperplasia
GO:0016601 ISS Rac protein signal transduction
GO:0030027 ISS lamellipodium
GO:0030041 IDA actin filament polymerization
GO:0030335 IEA positive regulation of cell migration
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032587 IDA ruffle membrane
GO:0032870 IEA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0042102 IDA positive regulation of T cell proliferation
GO:0042995 IEA cell projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0048662 IDA negative regulation of smooth muscle cell proliferation
GO:0048678 IEA response to axon injury
GO:0051015 IDA actin filament binding
GO:0051017 IDA actin filament bundle assembly
GO:0051602 IEA response to electrical stimulus
GO:0071315 IEA cellular response to morphine
GO:0071346 ISS cellular response to interferon-gamma
GO:0071447 IEA cellular response to hydroperoxide
GO:0071672 IDA negative regulation of smooth muscle cell chemotaxis
GO:0071673 IDA positive regulation of smooth muscle cell chemotaxis
GO:0090026 IDA positive regulation of monocyte chemotaxis
GO:0097178 ISS ruffle assembly
GO:1900087 IDA positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 IDA positive regulation of T cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000024397 Aif1 allograft inflammatory factor 1 protein_coding Mus_musculus

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