C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: allograft inflammatory factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024397 Aif1 10090 - 17:35170991-35176068 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025257 Aif1-002 35170994-35173278 protein_coding
  ENSMUST00000172679 Aif1-004 35170996-35176068 processed_transcript
  ENSMUST00000172693 Aif1-003 35170991-35172819 protein_coding
  ENSMUST00000173106 Aif1-006 35171523-35172631 protein_coding
  ENSMUST00000173281 Aif1-007 35170991-35171858 retained_intron
  ENSMUST00000173324 Aif1-001 35170992-35176001 protein_coding
  ENSMUST00000174044 Aif1-005 35172530-35176001 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025257ENSMUST00000172679ENSMUST00000172693ENSMUST00000173106ENSMUST00000173281ENSMUST00000173324ENSMUST00000174044
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025257 N/A 0.347±0.21 N/A 2.584±0.00 3.571±0.00 N/A N/A 0.446±0.00 1.026±0.46 N/A 0.046±0.00 1.396±1.12 N/A 932.713±0.00
ENSMUST00000172679 N/A N/A N/A N/A N/A N/A 0.093±0.00 N/A N/A N/A 0.285±0.00 0.357±0.00 0.388±0.15 N/A
ENSMUST00000172693 1.668±0.74 0.511±0.00 5.578±0.02 0.653±0.11 2.613±0.69 1.231±0.30 0.712±0.13 1.423±0.51 4.858±3.42 0.799±0.14 0.765±0.52 1.350±0.73 1.413±0.78 N/A
ENSMUST00000173106 N/A 0.250±0.00 N/A N/A N/A N/A N/A N/A N/A 0.369±0.05 0.230±0.09 1.362±0.77 0.359±0.13 N/A
ENSMUST00000173281 0.379±0.00 N/A N/A 3.541±0.00 0.740±0.00 0.368±0.00 0.414±0.00 0.105±0.00 1.000±0.00 N/A 0.668±0.16 2.830±2.00 0.903±0.18 N/A
ENSMUST00000173324 N/A N/A N/A N/A N/A N/A 1.078±0.00 0.314±0.00 N/A N/A N/A N/A N/A 97.620±40.86
ENSMUST00000174044 N/A 0.129±0.02 N/A N/A 0.490±0.16 0.130±0.04 N/A 0.080±0.00 N/A 0.125±0.04 N/A 0.280±0.07 0.072±0.00 90.465±10.22

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001726 IDA ruffle
GO:0001774 NAS microglial cell activation
GO:0001891 IDA phagocytic cup
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005509 IDA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 ISS cytosol
GO:0005884 IDA actin filament
GO:0006911 IMP phagocytosis, engulfment
GO:0006954 ISS inflammatory response
GO:0010629 IEA negative regulation of gene expression
GO:0014739 IEA positive regulation of muscle hyperplasia
GO:0016601 IMP Rac protein signal transduction
GO:0030027 IDA lamellipodium
GO:0030041 ISS actin filament polymerization
GO:0030335 IEA positive regulation of cell migration
GO:0031668 IEA cellular response to extracellular stimulus
GO:0032587 IDA ruffle membrane
GO:0032870 IEA cellular response to hormone stimulus
GO:0034097 IEA response to cytokine
GO:0042102 ISS positive regulation of T cell proliferation
GO:0042995 IEA cell projection
GO:0043066 IEA negative regulation of apoptotic process
GO:0043204 IEA perikaryon
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048661 ISS positive regulation of smooth muscle cell proliferation
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0048678 IEA response to axon injury
GO:0051015 ISS actin filament binding
GO:0051017 ISS actin filament bundle assembly
GO:0051602 IEA response to electrical stimulus
GO:0071315 IEA cellular response to morphine
GO:0071346 ISS cellular response to interferon-gamma
GO:0071447 IEA cellular response to hydroperoxide
GO:0071672 IEA negative regulation of smooth muscle cell chemotaxis
GO:0071673 ISS positive regulation of smooth muscle cell chemotaxis
GO:0090026 ISS positive regulation of monocyte chemotaxis
GO:0097178 IMP ruffle assembly
GO:1900087 ISS positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 ISS positive regulation of T cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000204472 AIF1 allograft inflammatory factor 1 protein_coding Homo_sapiens

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