Institute of Cardiovascular Regeneration Webtool Repository

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info
Description:	presenilin enhancer gamma secretase subunit
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSG00000205155	PSENEN	9606	+	19:35745114-35747519	protein_coding
	Transcript Accession		Transcript Name	Position	Transcript Biotype
	ENST00000222266		PSENEN-002	35745619-35747004	protein_coding
	ENST00000587708		PSENEN-001	35745114-35747519	protein_coding
	ENST00000591949		PSENEN-003	35745600-35746993	protein_coding

Expression Patterns

Transcript ID	Adipose	Adrenal	Brain	Breast	Colon	Heart	Kidney	Liver	Lung	Muscle	Ovary	Placenta	Testis
ENST00000222266	42.900±0.00	96.861±0.00	21.338±14.49	47.271±0.00	42.739±0.00	35.337±0.00	68.396±60.02	57.697±0.00	116.410±0.00	32.882±21.75	118.570±14.63	86.453±16.12	184.541±0.00

Conserved Regions
Gene is not located within a conserved region.

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0005515	IPI	protein binding
GO:0005783	IDA	endoplasmic reticulum
GO:0005794	IDA	Golgi apparatus
GO:0005886	TAS	plasma membrane
GO:0005887	IDA	integral component of plasma membrane
GO:0006509	IDA	membrane protein ectodomain proteolysis
GO:0007219	TAS	Notch signaling pathway
GO:0007220	TAS	Notch receptor processing
GO:0016485	IDA	protein processing
GO:0031293	TAS	membrane protein intracellular domain proteolysis
GO:0042987	TAS	amyloid precursor protein catabolic process
GO:0043065	TAS	positive regulation of apoptotic process
GO:0043085	IDA	positive regulation of catalytic activity
GO:0048011	TAS	neurotrophin TRK receptor signaling pathway
GO:0097190	TAS	apoptotic signaling pathway

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000068698	psenen	presenilin enhancer 2 homolog	protein_coding	Danio_rerio
ENSMUSG00000036835	Psenen	presenilin enhancer 2 homolog (C. elegans)	protein_coding	Mus_musculus

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