C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: intersectin 1 (SH3 domain protein)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000205726 ITSN1 9606 + 21:33642400-33899861 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000379960 ITSN1-201 33750107-33836635 protein_coding
  ENST00000381283 ITSN1-036 33718797-33772282 protein_coding
  ENST00000381284 ITSN1-004 33858697-33886354 protein_coding
  ENST00000381285 ITSN1-202 33642478-33889305 protein_coding
  ENST00000381291 ITSN1-002 33642478-33838494 protein_coding
  ENST00000381318 ITSN1-001 33642458-33899861 protein_coding
  ENST00000399338 ITSN1-203 33718810-33817614 protein_coding
  ENST00000399349 ITSN1-003 33642498-33838496 protein_coding
  ENST00000399352 ITSN1-024 33642496-33838498 protein_coding
  ENST00000399353 ITSN1-025 33642400-33837018 protein_coding
  ENST00000399355 ITSN1-037 33642498-33837293 protein_coding
  ENST00000399367 ITSN1-023 33642483-33888608 protein_coding
  ENST00000415023 ITSN1-005 33875360-33886354 protein_coding
  ENST00000419241 ITSN1-038 33797554-33817416 nonsense_mediated_decay
  ENST00000420666 ITSN1-031 33875358-33886377 nonsense_mediated_decay
  ENST00000428240 ITSN1-016 33818452-33829686 processed_transcript
  ENST00000437126 ITSN1-006 33818383-33834396 nonsense_mediated_decay
  ENST00000437442 ITSN1-204 33642478-33772058 protein_coding
  ENST00000440794 ITSN1-030 33799923-33817736 protein_coding
  ENST00000444491 ITSN1-033 33642452-33735204 protein_coding
  ENST00000451686 ITSN1-032 33642542-33735093 protein_coding
  ENST00000456489 ITSN1-017 33735041-33735626 protein_coding
  ENST00000462212 ITSN1-013 33829006-33837038 retained_intron
  ENST00000465143 ITSN1-035 33811204-33814507 retained_intron
  ENST00000470742 ITSN1-034 33642453-33721991 processed_transcript
  ENST00000472548 ITSN1-008 33829006-33837038 processed_transcript
  ENST00000474132 ITSN1-021 33774363-33775079 retained_intron
  ENST00000475422 ITSN1-011 33829006-33856793 retained_intron
  ENST00000479424 ITSN1-010 33829006-33837038 processed_transcript
  ENST00000487427 ITSN1-007 33818026-33829029 retained_intron
  ENST00000488166 ITSN1-019 33754183-33772300 processed_transcript
  ENST00000489261 ITSN1-012 33829006-33856793 retained_intron
  ENST00000495656 ITSN1-009 33829006-33856793 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000381283ENST00000381285ENST00000381291ENST00000381318ENST00000399338ENST00000399349ENST00000399352ENST00000399353ENST00000419241ENST00000451686ENST00000488166
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000381283 N/A N/A N/A N/A N/A 5.500±0.00 N/A 5.514±0.00 12.735±0.00 N/A N/A 3.775±0.00 N/A N/A
ENST00000381285 N/A N/A 0.552±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000381291 N/A N/A N/A 3.085±0.00 N/A N/A 0.748±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000381318 N/A N/A N/A 3.945±0.00 N/A N/A N/A N/A N/A 0.315±0.00 N/A N/A N/A N/A
ENST00000399338 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.028±0.00 N/A 2.656±0.00
ENST00000399349 10.790±0.00 1.907±0.00 N/A N/A 3.474±1.58 1.377±0.00 3.582±2.27 1.887±0.93 3.050±0.00 2.372±1.28 N/A 2.684±0.08 1.702±0.11 3.924±0.00
ENST00000399352 7.368±0.00 3.272±0.00 1.099±0.00 N/A 12.816±10.02 1.992±0.21 3.495±0.00 3.142±1.78 4.903±0.00 1.206±0.49 2.449±2.28 4.280±1.84 5.923±0.48 9.727±0.00
ENST00000399353 N/A N/A N/A N/A N/A 2.037±0.00 N/A N/A N/A N/A N/A 5.548±0.00 8.951±0.00 6.948±0.00
ENST00000419241 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.396±0.00 N/A N/A N/A
ENST00000451686 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.176±0.00 N/A N/A N/A
ENST00000488166 N/A N/A 5.377±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 20.421±0.00 15.321±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078C CIL_00078C_0001 CGP 21:33559542-33931607
CIL_0005TE CIL_0005TE_0001 CGP 21:33584687-33931607
CIL_00078A CIL_00078A_0001 CGP 21:33589341-33899861

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 NAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019209 IEA kinase activator activity
GO:0030027 IEA lamellipodium
GO:0030054 IEA cell junction
GO:0030139 IEA endocytic vesicle
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032947 IDA protein complex scaffold
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042327 IEA positive regulation of phosphorylation
GO:0043005 IEA neuron projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0045202 IEA synapse
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048488 TAS synaptic vesicle endocytosis
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070064 IPI proline-rich region binding
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000000086 itsn1 intersectin 1 (SH3 domain protein) protein_coding Danio_rerio
ENSMUSG00000022957 Itsn1 intersectin 1 (SH3 domain protein 1A) protein_coding Mus_musculus

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