C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: intersectin 1 (SH3 domain protein)
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000381318 ITSN1-001 ENSG00000205726 9606 + 21:33642458-33899861 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainLungENST00000381318
Transcript ID Brain Lung
ENST00000381318 3.945±0.00 0.315±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00078C CIL_00078C_0001 CGP 21:33559542-33931607
CIL_0005TE CIL_0005TE_0001 CGP 21:33584687-33931607
CIL_00078A CIL_00078A_0001 CGP 21:33589341-33899861

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 NAS guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005509 IEA:NAS calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005905 IDA coated pit
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019209 IEA kinase activator activity
GO:0030027 IEA lamellipodium
GO:0030054 IEA cell junction
GO:0030139 IEA endocytic vesicle
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032947 IDA protein complex scaffold
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042327 IEA positive regulation of phosphorylation
GO:0043005 IEA neuron projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043547 NAS positive regulation of GTPase activity
GO:0045202 IEA synapse
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048488 TAS synaptic vesicle endocytosis
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0070064 IPI proline-rich region binding
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000064797 Itsn1-008 protein_coding Mus_musculus 0 6397
ENSMUST00000114002 Itsn1-001 protein_coding Mus_musculus 0 6300
ENSMUST00000113999 Itsn1-006 protein_coding Mus_musculus 0 4375
ENSMUST00000056482 Itsn1-003 protein_coding Mus_musculus 0 4263
ENSMUST00000114001 Itsn1-004 protein_coding Mus_musculus 0 3463
ENSMUST00000113996 Itsn1-010 protein_coding Mus_musculus 0 3408
ENSMUST00000113993 Itsn1-005 protein_coding Mus_musculus 0 3338
ENSMUST00000095909 Itsn1-002 protein_coding Mus_musculus 0 2263
ENSMUST00000135057 Itsn1-009 protein_coding Mus_musculus 0 797
ENSMUST00000125052 Itsn1-016 protein_coding Mus_musculus 0 765
ENSMUST00000151044 Itsn1-024 processed_transcript Mus_musculus 0 676
ENSMUST00000131983 Itsn1-021 retained_intron Mus_musculus 0 531
ENSMUST00000141073 Itsn1-028 processed_transcript Mus_musculus 0 525
ENSMUST00000138117 Itsn1-015 retained_intron Mus_musculus 0 497
ENSMUST00000141625 Itsn1-018 protein_coding Mus_musculus 0 483
ENSMUST00000143023 Itsn1-027 protein_coding Mus_musculus 0 477
ENSMUST00000124094 Itsn1-022 processed_transcript Mus_musculus 0 455
ENSMUST00000131739 Itsn1-017 nonsense_mediated_decay Mus_musculus 0 364
ENSMUST00000133389 Itsn1-007 processed_transcript Mus_musculus 0 357
ENSMUST00000156841 Itsn1-023 retained_intron Mus_musculus 0 224
ENSMUST00000126374 Itsn1-013 nonsense_mediated_decay Mus_musculus 0 204
ENSMUST00000144101 Itsn1-025 retained_intron Mus_musculus 0 196
ENSMUST00000173269 Neu1-002 retained_intron Mus_musculus 0.000007 60
ENSMUST00000034431 Tmem170-201 protein_coding Mus_musculus 0.00009 57

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