C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: deiodinase, iodothyronine, type I
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000211452 DIO1 9606 + 1:53891239-53911086 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000322679 DIO1-002 53894188-53911084 protein_coding
  ENST00000361921 DIO1-001 53894187-53911086 protein_coding
  ENST00000388876 DIO1-009 53894211-53909999 protein_coding
  ENST00000524406 DIO1-014 53894211-53909999 protein_coding
  ENST00000525044 DIO1-006 53894189-53910109 nonsense_mediated_decay
  ENST00000525202 DIO1-013 53894211-53909999 protein_coding
  ENST00000526329 DIO1-015 53894192-53904854 retained_intron
  ENST00000527060 DIO1-007 53894189-53910109 nonsense_mediated_decay
  ENST00000528946 DIO1-003 53894189-53910109 nonsense_mediated_decay
  ENST00000529329 DIO1-011 53894211-53909999 nonsense_mediated_decay
  ENST00000529589 DIO1-017 53892167-53906294 protein_coding
  ENST00000530084 DIO1-004 53894189-53910107 nonsense_mediated_decay
  ENST00000532493 DIO1-010 53894211-53909999 protein_coding
  ENST00000534069 DIO1-016 53891239-53906160 processed_transcript
  ENST00000610607 DIO1-201 53894189-53910109 protein_coding
  ENST00000613679 DIO1-202 53894188-53911085 protein_coding
  ENST00000617230 DIO1-203 53894188-53911085 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartKidneyLiverLungOvaryPlacentaTestisENST00000322679ENST00000361921ENST00000525202ENST00000526329ENST00000527060ENST00000528946ENST00000529329ENST00000532493ENST00000613679ENST00000617230
Transcript ID Adipose Bladder Brain Breast Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000322679 0.024±0.00 N/A 0.004±0.00 0.034±0.01 0.015±0.00 5.818±0.00 N/A N/A 0.048±0.03 0.014±0.00 N/A
ENST00000361921 N/A N/A N/A N/A N/A N/A N/A N/A 0.046±0.00 N/A N/A
ENST00000525202 N/A N/A N/A N/A N/A N/A N/A 0.722±0.00 N/A N/A 0.262±0.00
ENST00000526329 0.057±0.00 N/A N/A N/A N/A N/A N/A N/A 0.198±0.00 N/A N/A
ENST00000527060 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.192±0.00
ENST00000528946 N/A N/A N/A 0.055±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000529329 N/A N/A N/A N/A N/A N/A N/A N/A 0.091±0.00 N/A N/A
ENST00000532493 N/A N/A N/A 0.082±0.00 N/A N/A N/A N/A 0.182±0.00 0.167±0.00 N/A
ENST00000613679 N/A 1.558±0.00 N/A N/A N/A 13.879±7.83 13.779±0.00 N/A 0.054±0.00 N/A N/A
ENST00000617230 0.022±0.00 N/A 0.004±0.00 0.032±0.01 0.013±0.00 N/A N/A N/A 0.045±0.03 0.013±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004800 IEA thyroxine 5'-deiodinase activity
GO:0005783 IEA endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0006590 TAS thyroid hormone generation
GO:0008430 IEA selenium binding
GO:0016021 IEA integral component of membrane
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042446 IEA hormone biosynthetic process
GO:0044281 TAS small molecule metabolic process
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042112 dio1 deiodinase, iodothyronine, type I protein_coding Danio_rerio
ENSMUSG00000034785 Dio1 deiodinase, iodothyronine, type I protein_coding Mus_musculus

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