C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 4B (Chido blood group)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000224389 C4B 9606 + 6:32014762-32035418 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000425700 C4B-201 32014846-32035417 protein_coding
  ENST00000435363 C4B-001 32014762-32035418 protein_coding
  ENST00000461632 C4B-005 32024915-32026714 retained_intron
  ENST00000463249 C4B-010 32031937-32035234 retained_intron
  ENST00000468237 C4B-002 32033735-32035401 retained_intron
  ENST00000468936 C4B-011 32031892-32035403 retained_intron
  ENST00000473957 C4B-016 32033944-32034331 retained_intron
  ENST00000474912 C4B-006 32027320-32028365 retained_intron
  ENST00000478388 C4B-009 32031588-32032267 retained_intron
  ENST00000478438 C4B-015 32027146-32028090 retained_intron
  ENST00000485263 C4B-008 32030479-32032456 retained_intron
  ENST00000485543 C4B-004 32015619-32017136 processed_transcript
  ENST00000486992 C4B-017 32030395-32032298 retained_intron
  ENST00000490071 C4B-003 32015581-32016297 retained_intron
  ENST00000496065 C4B-012 32033864-32035002 retained_intron
  ENST00000496560 C4B-007 32033997-32034605 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000425700
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000425700 0.462±0.00 0.505±0.00 0.208±0.00 0.361±0.33 0.355±0.08 0.622±0.57 0.337±0.30 5.387±1.42 6.933±6.90 0.465±0.37 0.042±0.00 1.653±1.59 0.319±0.07 0.811±0.72

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000424 CIL_000424_0001 CGP 6:32014762-32041670

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001848 IDA complement binding
GO:0004866 IEA endopeptidase inhibitor activity
GO:0005515 IEA protein binding
GO:0005576 IEA extracellular region
GO:0005615 IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0006954 IEA inflammatory response
GO:0006956 IEA complement activation
GO:0006958 IEA complement activation, classical pathway
GO:0008228 TAS opsonization
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0030246 IDA carbohydrate binding
GO:0030449 TAS regulation of complement activation
GO:0032490 IDA detection of molecule of bacterial origin
GO:0044216 IDA other organism cell
GO:0045087 TAS innate immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle
GO:2000427 IGI positive regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038424 si:dkey-8k3.2 complement component 4B (Chido blood group) protein_coding Danio_rerio
ENSMUSG00000073418 C4b complement component 4B (Chido blood group) protein_coding Mus_musculus

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