C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement factor B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000243649 CFB 9606 + 6:31945650-31952084 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000425368 CFB-001 31945709-31952084 protein_coding
  ENST00000452035 CFB-003 31946222-31950645 retained_intron
  ENST00000460718 CFB-005 31946126-31947969 nonsense_mediated_decay
  ENST00000461483 CFB-006 31947281-31949551 retained_intron
  ENST00000465750 CFB-008 31948358-31949598 retained_intron
  ENST00000467150 CFB-009 31948998-31949598 retained_intron
  ENST00000467360 CFB-010 31949731-31951244 retained_intron
  ENST00000472581 CFB-004 31945975-31947120 retained_intron
  ENST00000475617 CFB-002 31945650-31947141 protein_coding
  ENST00000482312 CFB-011 31950874-31952084 retained_intron
  ENST00000482886 CFB-014 31948460-31949257 retained_intron
  ENST00000483004 CFB-013 31948956-31952053 protein_coding
  ENST00000497841 CFB-007 31947797-31949598 processed_transcript
  ENST00000498317 CFB-012 31951415-31952084 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBreastColonHeartKidneyLiverMuscleOvaryTestisENST00000425368ENST00000452035ENST00000460718ENST00000465750ENST00000472581ENST00000475617ENST00000483004
Transcript ID Adrenal Bladder Breast Colon Heart Kidney Liver Muscle Ovary Testis
ENST00000425368 N/A 0.843±0.00 N/A 3.290±0.00 N/A 143.854±123.32 253.908±252.71 0.664±0.00 17.818±0.00 5.506±0.00
ENST00000452035 N/A N/A N/A N/A 0.519±0.00 N/A N/A 0.119±0.00 N/A N/A
ENST00000460718 N/A 2.201±0.00 N/A N/A N/A N/A 5.604±0.00 0.444±0.00 N/A N/A
ENST00000465750 N/A N/A N/A N/A 1.672±0.00 N/A N/A 0.565±0.00 N/A N/A
ENST00000472581 N/A N/A N/A N/A N/A N/A 2.898±0.00 N/A N/A N/A
ENST00000475617 N/A 4.613±0.00 36.806±0.00 N/A N/A 765.232±0.00 7.868±0.00 1.272±0.00 N/A N/A
ENST00000483004 18.112±0.00 N/A N/A N/A N/A 49.206±0.00 888.612±0.00 0.151±0.00 N/A 11.422±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000421 CIL_000421_0001 CGP 6:31897785-31945672
CIL_0001PM CIL_0001PM_0003 CGP 6:31927698-31952084

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001848 TAS complement binding
GO:0003824 IEA catalytic activity
GO:0004252 TAS:IEA serine-type endopeptidase activity
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0006508 IEA proteolysis
GO:0006956 TAS:IEA complement activation
GO:0006957 NAS complement activation, alternative pathway
GO:0030449 TAS regulation of complement activation
GO:0045087 TAS innate immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005616 bfb complement component bfb protein_coding Danio_rerio
ENSDARG00000055278 cfb complement factor B protein_coding Danio_rerio
ENSDARG00000090730 zgc:158446 zgc:158446 protein_coding Danio_rerio
ENSMUSG00000090231 Cfb complement factor B protein_coding Mus_musculus
ENSMUSG00000092511 Gm20547 predicted gene 20547 protein_coding Mus_musculus

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