C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: programmed cell death 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000249915 PDCD6 9606 + 5:271621-353856 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264933 PDCD6-001 271621-314974 protein_coding
  ENST00000505221 PDCD6-011 271647-314806 protein_coding
  ENST00000505526 PDCD6-002 271661-312411 nonsense_mediated_decay
  ENST00000506909 PDCD6-014 271670-353856 nonsense_mediated_decay
  ENST00000507473 PDCD6-012 272712-314686 protein_coding
  ENST00000507528 PDCD6-008 271657-314969 protein_coding
  ENST00000509581 PDCD6-006 271657-276940 protein_coding
  ENST00000511482 PDCD6-009 306681-314954 processed_transcript
  ENST00000512466 PDCD6-007 308197-314973 retained_intron
  ENST00000513582 PDCD6-003 271625-314969 retained_intron
  ENST00000515587 PDCD6-005 271624-273367 retained_intron
  ENST00000614778 PDCD6-201 271621-314974 protein_coding
  ENST00000618970 PDCD6-202 271621-314974 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264933ENST00000505526ENST00000507473ENST00000507528ENST00000509581ENST00000512466ENST00000513582ENST00000614778
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264933 12.278±0.00 25.538±0.00 2.293±0.00 14.899±3.75 22.226±0.00 17.461±0.00 14.188±0.00 25.013±22.89 12.510±7.17 10.669±5.16 13.345±0.00 35.663±10.55 35.942±7.23 26.108±12.72
ENST00000505526 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.863±0.00 N/A N/A
ENST00000507473 N/A N/A N/A N/A N/A N/A N/A N/A N/A 17.514±0.00 5.009±0.00 N/A N/A N/A
ENST00000507528 8.021±0.00 25.259±0.00 N/A 12.316±6.99 18.253±0.00 5.812±0.02 N/A N/A 3.585±1.51 N/A N/A 15.311±6.97 14.961±6.26 21.577±0.00
ENST00000509581 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.366±0.00 N/A N/A N/A
ENST00000512466 N/A N/A 0.429±0.00 N/A 1.151±0.00 N/A N/A 0.448±0.00 N/A 1.012±0.00 0.150±0.00 N/A N/A N/A
ENST00000513582 N/A N/A N/A N/A 2.674±0.00 1.714±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000614778 N/A N/A N/A 6.782±0.00 6.933±0.00 7.176±1.98 2.374±0.00 3.935±0.00 N/A 3.056±0.00 1.901±0.00 16.200±6.60 N/A 12.040±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0004198 IBA calcium-dependent cysteine-type endopeptidase activity
GO:0005509 ISS:IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0006508 IBA proteolysis
GO:0006886 IDA intracellular protein transport
GO:0006915 IEA apoptotic process
GO:0006919 IEA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0016020 IEA membrane
GO:0030948 IDA negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031410 IDA cytoplasmic vesicle
GO:0032007 IDA negative regulation of TOR signaling
GO:0034605 IDA cellular response to heat
GO:0036324 IDA vascular endothelial growth factor receptor-2 signaling pathway
GO:0042803 IEA protein homodimerization activity
GO:0045766 IDA positive regulation of angiogenesis
GO:0046983 IPI protein dimerization activity
GO:0048306 IPI calcium-dependent protein binding
GO:0051592 ISS response to calcium ion
GO:0051898 IDA negative regulation of protein kinase B signaling
GO:0060090 IMP binding, bridging
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005220 pdcd6 programmed cell death 6 protein_coding Danio_rerio
ENSMUSG00000021576 Pdcd6 programmed cell death 6 protein_coding Mus_musculus

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