C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth differentiation factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000263761 GDF2 9606 + 10:47322490-47326270 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000581492 GDF2-001 47322490-47326270 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainBreastHeartKidneyPlacentaTestisENST00000581492
Transcript ID Brain Breast Heart Kidney Placenta Testis
ENST00000581492 0.027±0.00 0.021±0.00 0.080±0.00 3.235±0.00 0.099±0.05 0.053±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006FX CIL_0006FX_0002 CGP 10:47300386-47326270
CIL_0006P7 CIL_0006P7_0002 CGP 10:47322490-47357875

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001503 TAS ossification
GO:0001525 IMP angiogenesis
GO:0001569 IDA patterning of blood vessels
GO:0001570 IEA vasculogenesis
GO:0001649 IEA osteoblast differentiation
GO:0001937 IDA negative regulation of endothelial cell proliferation
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0005125 IEA cytokine activity
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0006879 TAS cellular iron ion homeostasis
GO:0008083 IEA growth factor activity
GO:0008156 TAS negative regulation of DNA replication
GO:0010596 IDA negative regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016525 TAS negative regulation of angiogenesis
GO:0030308 IDA negative regulation of cell growth
GO:0030509 IDA BMP signaling pathway
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0032757 IDA positive regulation of interleukin-8 production
GO:0032924 IDA activin receptor signaling pathway
GO:0040007 IEA growth
GO:0043537 TAS negative regulation of blood vessel endothelial cell migration
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045766 IDA positive regulation of angiogenesis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048514 IDA blood vessel morphogenesis
GO:0051216 TAS cartilage development
GO:0060389 IDA pathway-restricted SMAD protein phosphorylation
GO:0070062 IDA extracellular vesicular exosome
GO:0071773 IDA cellular response to BMP stimulus
GO:2000279 IDA negative regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000059173 gdf2 growth differentiation factor 2 protein_coding Danio_rerio
ENSMUSG00000072625 Gdf2 growth differentiation factor 2 protein_coding Mus_musculus

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