C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin II
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000000215 Ins2 10090 - 7:142678656-142699510 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000000220 Ins2-001 142678659-142679726 protein_coding
  ENSMUST00000105930 Ins2-004 142678659-142679692 protein_coding
  ENSMUST00000105931 Ins2-003 142678656-142679685 protein_coding
  ENSMUST00000105932 Ins2-005 142678661-142679717 protein_coding
  ENSMUST00000105933 Ins2-002 142678659-142679698 protein_coding
  ENSMUST00000105934 Ins2-006 142678656-142699510 protein_coding
  ENSMUST00000125933 Ins2-007 142678709-142679580 protein_coding
  ENSMUST00000162317 Ins2-008 142678713-142679533 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000000220ENSMUST00000105930ENSMUST00000105931ENSMUST00000105932ENSMUST00000105933ENSMUST00000105934ENSMUST00000125933ENSMUST00000162317
Transcript ID Adipose Bladder Brain Breast Colon Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000000220 N/A N/A N/A N/A 6.772±2.00 0.373±0.00 0.234±0.15 N/A N/A 0.249±0.00 0.028±0.00 0.088±0.00
ENSMUST00000105930 N/A N/A 0.071±0.00 N/A N/A 0.052±0.00 N/A 0.078±0.00 N/A N/A N/A 0.072±0.01
ENSMUST00000105931 N/A N/A 0.068±0.01 N/A N/A N/A N/A N/A N/A 0.248±0.00 N/A N/A
ENSMUST00000105932 0.181±0.00 N/A 0.268±0.00 0.374±0.08 37.898±3.15 0.290±0.11 0.586±0.61 0.230±0.00 0.182±0.00 0.217±0.17 0.159±0.03 0.145±0.05
ENSMUST00000105933 N/A 0.020±0.00 0.094±0.00 N/A N/A N/A N/A N/A N/A N/A 0.020±0.00 N/A
ENSMUST00000105934 N/A 0.026±0.00 0.126±0.00 N/A N/A N/A 0.039±0.00 N/A 0.094±0.00 N/A N/A 0.049±0.00
ENSMUST00000125933 N/A N/A 0.311±0.00 1.215±0.00 N/A 0.503±0.30 N/A N/A N/A N/A N/A N/A
ENSMUST00000162317 N/A N/A N/A N/A N/A N/A N/A 0.289±0.00 N/A N/A N/A 0.435±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MR CIL_0008MR_0002 VISTA 7:142247512-142849546
CIL_0007RG CIL_0007RG_0002 VISTA 7:142251566-142854813
CIL_00097V CIL_00097V_0002 VISTA 7:142268912-142873912

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000187 IDA activation of MAPK activity
GO:0002020 IEA protease binding
GO:0005179 IEA hormone activity
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005634 IDA nucleus
GO:0005732 IDA small nucleolar ribonucleoprotein complex
GO:0005737 IDA cytoplasm
GO:0006006 IMP glucose metabolic process
GO:0006983 IMP ER overload response
GO:0007520 IGI myoblast fusion
GO:0008286 IDA insulin receptor signaling pathway
GO:0010468 IDA regulation of gene expression
GO:0014902 IGI myotube differentiation
GO:0015758 TAS glucose transport
GO:0016042 IDA lipid catabolic process
GO:0030141 IDA secretory granule
GO:0032403 IEA protein complex binding
GO:0034774 TAS secretory granule lumen
GO:0042325 IDA regulation of phosphorylation
GO:0043393 IDA regulation of protein binding
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0060070 IGI canonical Wnt signaling pathway
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000034610 insb preproinsulin b protein_coding Danio_rerio
ENSDARG00000035350 ins preproinsulin protein_coding Danio_rerio
ENSG00000254647 INS insulin protein_coding Homo_sapiens

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