C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: thymoma viral proto-oncogene 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000001729 Akt1 10090 - 12:112653821-112674884 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000001780 Akt1-001 112653821-112674276 protein_coding
  ENSMUST00000123563 Akt1-008 112657094-112659637 retained_intron
  ENSMUST00000127588 Akt1-007 112657562-112659142 retained_intron
  ENSMUST00000127902 Akt1-005 112659637-112674206 processed_transcript
  ENSMUST00000128300 Akt1-006 112654673-112671564 protein_coding
  ENSMUST00000130342 Akt1-003 112659160-112673944 protein_coding
  ENSMUST00000139388 Akt1-004 112659266-112668114 processed_transcript
  ENSMUST00000144550 Akt1-002 112658425-112674884 protein_coding
  ENSMUST00000159815 Akt1-009 112655843-112656973 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000001780ENSMUST00000123563ENSMUST00000128300
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000001780 23.587±10.33 56.030±0.00 42.250±14.43 73.339±38.25 12.580±1.96 47.040±15.18 35.218±10.34 10.868±3.83 15.819±10.01 13.496±2.21 18.235±3.83 68.798±45.92 139.539±115.16 4.000±1.60
ENSMUST00000123563 N/A N/A N/A 72.605±0.00 N/A N/A N/A N/A N/A N/A N/A 102.657±0.00 251.556±71.03 8.154±0.00
ENSMUST00000128300 N/A 74.060±0.00 N/A N/A 22.429±0.00 N/A N/A N/A N/A N/A N/A 44.805±2.68 66.665±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001G0 CIL_0001G0_0002 CGP 12:112644828-112674884
CIL_00030T CIL_00030T_0002 CGP 12:112653821-112682747

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IEA protein import into nucleus, translocation
GO:0001649 IGI osteoblast differentiation
GO:0001893 IMP maternal placenta development
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 ISS positive regulation of endothelial cell proliferation
GO:0004672 IDA protein kinase activity
GO:0004674 IDA:ISS protein serine/threonine kinase activity
GO:0004712 ISO protein serine/threonine/tyrosine kinase activity
GO:0005080 IEA protein kinase C binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005547 IEA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005819 IDA spindle
GO:0005829 TAS cytosol
GO:0005886 ISO plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005977 IMP glycogen metabolic process
GO:0005978 IEA glycogen biosynthetic process
GO:0005979 IEA regulation of glycogen biosynthetic process
GO:0006006 IMP glucose metabolic process
GO:0006412 IEA translation
GO:0006417 IEA regulation of translation
GO:0006468 IDA protein phosphorylation
GO:0006469 IEA negative regulation of protein kinase activity
GO:0006924 ISO activation-induced cell death of T cells
GO:0006954 IDA inflammatory response
GO:0006979 ISS response to oxidative stress
GO:0007010 TAS cytoskeleton organization
GO:0007165 IEA signal transduction
GO:0007281 IDA germ cell development
GO:0007568 IEA aging
GO:0008286 ISS insulin receptor signaling pathway
GO:0008637 IDA apoptotic mitochondrial changes
GO:0009725 IDA response to hormone
GO:0010507 IEA negative regulation of autophagy
GO:0010748 IEA negative regulation of plasma membrane long-chain fatty acid transport
GO:0010765 IDA positive regulation of sodium ion transport
GO:0010907 IEA positive regulation of glucose metabolic process
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0010975 IDA regulation of neuron projection development
GO:0015630 IEA microtubule cytoskeleton
GO:0015758 IMP glucose transport
GO:0016301 ISO kinase activity
GO:0016310 IEA phosphorylation
GO:0016567 IDA protein ubiquitination
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019899 IEA enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030030 ISO cell projection organization
GO:0030163 IDA protein catabolic process
GO:0030212 IEA hyaluronan metabolic process
GO:0030235 IEA nitric-oxide synthase regulator activity
GO:0030307 IEA positive regulation of cell growth
GO:0030334 ISS regulation of cell migration
GO:0031018 TAS endocrine pancreas development
GO:0031641 IMP regulation of myelination
GO:0031659 IEA positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031999 IEA negative regulation of fatty acid beta-oxidation
GO:0032094 IDA response to food
GO:0032270 IEA positive regulation of cellular protein metabolic process
GO:0032287 IMP peripheral nervous system myelin maintenance
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032869 IDA cellular response to insulin stimulus
GO:0032880 IDA regulation of protein localization
GO:0033138 IEA positive regulation of peptidyl-serine phosphorylation
GO:0034405 IEA response to fluid shear stress
GO:0035556 ISO intracellular signal transduction
GO:0036064 IDA ciliary basal body
GO:0042593 IMP glucose homeostasis
GO:0042802 IEA identical protein binding
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043154 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043325 IEA phosphatidylinositol-3,4-bisphosphate binding
GO:0043491 IGI protein kinase B signaling
GO:0043536 IEA positive regulation of blood vessel endothelial cell migration
GO:0045429 IEA positive regulation of nitric oxide biosynthetic process
GO:0045600 IEA positive regulation of fat cell differentiation
GO:0045725 IEA positive regulation of glycogen biosynthetic process
GO:0045792 ISO negative regulation of cell size
GO:0045861 IEA negative regulation of proteolysis
GO:0045907 IEA positive regulation of vasoconstriction
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0046326 IEA positive regulation of glucose import
GO:0046329 IEA negative regulation of JNK cascade
GO:0046889 IEA positive regulation of lipid biosynthetic process
GO:0048009 ISS insulin-like growth factor receptor signaling pathway
GO:0051000 IEA positive regulation of nitric-oxide synthase activity
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 IGI striated muscle cell differentiation
GO:0060709 IMP glycogen cell differentiation involved in embryonic placenta development
GO:0060716 IMP labyrinthine layer blood vessel development
GO:0070141 IEA response to UV-A
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071364 IDA cellular response to epidermal growth factor stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071456 IEA cellular response to hypoxia
GO:0071889 IEA 14-3-3 protein binding
GO:0090004 IEA positive regulation of establishment of protein localization to plasma membrane
GO:0090201 IDA negative regulation of release of cytochrome c from mitochondria
GO:0097011 IDA cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097194 IDA execution phase of apoptosis
GO:1901653 IDA cellular response to peptide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000142208 AKT1 v-akt murine thymoma viral oncogene homolog 1 protein_coding Homo_sapiens

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