C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SH2B adaptor protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005057 Sh2b2 10090 - 5:136218149-136244903 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005188 Sh2b2-201 136218149-136244903 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005188
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005188 20.851±4.82 19.654±5.40 0.772±0.03 11.260±7.13 25.895±6.86 0.901±0.32 1.011±0.54 2.430±0.90 1.118±0.63 1.669±0.67 0.757±0.21 6.966±3.25 6.939±3.34 0.542±0.16

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001725 IDA stress fiber
GO:0001726 IDA ruffle
GO:0001922 IMP B-1 B cell homeostasis
GO:0004871 IEA signal transducer activity
GO:0005068 IDA transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005884 IDA actin filament
GO:0005886 ISS plasma membrane
GO:0007399 IEA nervous system development
GO:0008269 IEA JAK pathway signal transduction adaptor activity
GO:0008286 IDA insulin receptor signaling pathway
GO:0009967 IDA positive regulation of signal transduction
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019222 IMP regulation of metabolic process
GO:0030036 IMP actin cytoskeleton organization
GO:0035556 IDA intracellular signal transduction
GO:0042593 ISA glucose homeostasis
GO:0042802 IEA identical protein binding
GO:0046325 ISA negative regulation of glucose import
GO:0046425 IEA regulation of JAK-STAT cascade
GO:0046578 IEA regulation of Ras protein signal transduction
GO:0050776 IMP regulation of immune response
GO:0050851 IDA antigen receptor-mediated signaling pathway
GO:0050873 IDA brown fat cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090421 SH2B2 SH2B adaptor protein 2 protein_coding Danio_rerio
ENSG00000160999 SH2B2 SH2B adaptor protein 2 protein_coding Homo_sapiens

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