C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SH2B adaptor protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160999 SH2B2 9606 + 7:102285091-102321711 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000444095 SH2B2-003 102286888-102301279 protein_coding
  ENST00000536178 SH2B2-001 102285155-102321711 protein_coding
  ENST00000617975 SH2B2-002 102285091-102314547 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000444095ENST00000536178ENST00000617975
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000444095 N/A N/A N/A N/A N/A N/A 0.376±0.00 N/A N/A N/A N/A N/A N/A
ENST00000536178 1.539±0.00 6.774±0.00 0.047±0.00 0.691±0.27 2.653±0.00 0.213±0.00 N/A 1.611±0.00 0.326±0.00 N/A 3.231±2.75 2.051±0.65 1.243±0.00
ENST00000617975 N/A N/A N/A N/A N/A 1.317±0.00 N/A N/A N/A 0.356±0.00 N/A 2.089±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002FZ CIL_0002FZ_0002 CGP 7:101815904-102321711

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001725 IEA stress fiber
GO:0001726 IEA ruffle
GO:0001922 IEA B-1 B cell homeostasis
GO:0004871 IEA signal transducer activity
GO:0005068 IEA transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005070 IDA SH3/SH2 adaptor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005884 IEA actin filament
GO:0005886 IDA plasma membrane
GO:0007165 TAS signal transduction
GO:0007399 IEA nervous system development
GO:0007596 TAS blood coagulation
GO:0008269 IDA JAK pathway signal transduction adaptor activity
GO:0008286 ISS insulin receptor signaling pathway
GO:0009967 IEA positive regulation of signal transduction
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019222 IEA regulation of metabolic process
GO:0030036 IEA actin cytoskeleton organization
GO:0035556 IEA intracellular signal transduction
GO:0042802 IEA identical protein binding
GO:0046425 IDA regulation of JAK-STAT cascade
GO:0046578 IEA regulation of Ras protein signal transduction
GO:0050776 IEA regulation of immune response
GO:0050851 IEA antigen receptor-mediated signaling pathway
GO:0050873 IEA brown fat cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000090421 SH2B2 SH2B adaptor protein 2 protein_coding Danio_rerio
ENSMUSG00000005057 Sh2b2 SH2B adaptor protein 2 protein_coding Mus_musculus

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