C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: prostaglandin I2 (prostacyclin) synthase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017969 Ptgis 10090 - 2:167191805-167240604 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018113 Ptgis-001 167202907-167240604 protein_coding
  ENSMUST00000088041 Ptgis-002 167191805-167240589 protein_coding
  ENSMUST00000136271 Ptgis-003 167206522-167208416 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENSMUST00000018113ENSMUST00000088041
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENSMUST00000018113 12.976±5.02 11.011±1.60 39.920±1.06 1.665±0.30 3.561±1.15 4.450±1.06 9.043±1.49 2.817±0.30 0.506±0.26 38.978±4.51 25.726±7.57 4.500±2.30 2.480±1.20
ENSMUST00000088041 14.580±4.17 30.445±2.63 13.540±3.78 N/A 5.326±2.31 7.854±1.59 5.121±0.35 1.837±0.70 0.463±0.23 29.627±13.68 36.712±14.94 4.220±1.64 2.354±0.77

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008I4 CIL_0008I4_0002 VISTA 2:167024358-167627099
CIL_0006IT CIL_0006IT_0003 CGP 2:167103378-167240604
CIL_0001RU CIL_0001RU_0002 CGP 2:167191805-167349183

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 ISS prostaglandin biosynthetic process
GO:0004497 IEA monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005615 ISS extracellular space
GO:0005634 ISS nucleus
GO:0005783 ISS endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005901 ISS caveola
GO:0008116 ISS prostaglandin-I synthase activity
GO:0016021 IEA integral component of membrane
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 IBA heme binding
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0035360 ISS positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042981 IBA regulation of apoptotic process
GO:0045019 ISS negative regulation of nitric oxide biosynthetic process
GO:0045766 ISS positive regulation of angiogenesis
GO:0050728 ISS negative regulation of inflammatory response
GO:0055114 IEA oxidation-reduction process
GO:0071347 ISS cellular response to interleukin-1
GO:0071354 ISS cellular response to interleukin-6
GO:0071456 ISS cellular response to hypoxia
GO:0097190 IEA apoptotic signaling pathway
GO:1900119 ISS positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060094 ptgis prostaglandin I2 (prostacyclin) synthase protein_coding Danio_rerio
ENSG00000124212 PTGIS prostaglandin I2 (prostacyclin) synthase protein_coding Homo_sapiens

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