C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: pro-opiomelanocortin-alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020660 Pomc 10090 + 12:3954951-3960618 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020990 Pomc-201 3954951-3960618 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020990
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020990 0.300±0.08 0.220±0.07 0.233±0.01 1.600±0.62 0.307±0.08 0.244±0.08 0.118±0.02 0.352±0.18 0.207±0.13 0.282±0.05 0.166±0.10 0.523±0.22 0.484±0.15 3.033±0.33

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00070X CIL_00070X_0002 CGP 12:3954951-4038915

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 ISS G-protein coupled receptor binding
GO:0005102 IEA receptor binding
GO:0005179 IDA hormone activity
GO:0005615 ISS extracellular space
GO:0005737 IDA cytoplasm
GO:0005782 IEA peroxisomal matrix
GO:0006091 ISS generation of precursor metabolites and energy
GO:0007165 ISS signal transduction
GO:0007218 IEA neuropeptide signaling pathway
GO:0007267 ISS cell-cell signaling
GO:0008217 IGI regulation of blood pressure
GO:0030141 IDA secretory granule
GO:0031781 IEA type 3 melanocortin receptor binding
GO:0031782 IEA type 4 melanocortin receptor binding
GO:0032098 ISS regulation of appetite
GO:0032720 ISS negative regulation of tumor necrosis factor production
GO:0033059 ISS cellular pigmentation
GO:0042593 IMP glucose homeostasis
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0070873 IMP regulation of glycogen metabolic process
GO:0070996 ISS type 1 melanocortin receptor binding
GO:2000852 IMP regulation of corticosterone secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043135 pomca proopiomelanocortin a protein_coding Danio_rerio
ENSDARG00000069307 pomcb proopiomelanocortin b protein_coding Danio_rerio
ENSG00000115138 POMC proopiomelanocortin protein_coding Homo_sapiens

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