C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proopiomelanocortin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115138 POMC 9606 - 2:25160853-25168903 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264708 POMC-002 25160985-25168571 protein_coding
  ENST00000380794 POMC-201 25160853-25168690 protein_coding
  ENST00000395826 POMC-004 25161053-25168604 protein_coding
  ENST00000405623 POMC-001 25160915-25168903 protein_coding
  ENST00000449220 POMC-003 25161146-25168571 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264708ENST00000380794ENST00000395826ENST00000405623ENST00000449220
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264708 N/A N/A N/A N/A N/A N/A N/A 0.121±0.00 0.602±0.00 0.403±0.00 N/A N/A 1.071±0.00
ENST00000380794 N/A 0.125±0.00 0.025±0.00 0.698±0.00 0.391±0.00 0.281±0.00 N/A N/A 0.500±0.00 N/A 0.312±0.12 3.733±2.66 1.529±0.00
ENST00000395826 0.492±0.00 0.939±0.00 1.394±0.00 4.124±0.00 0.857±0.00 0.558±0.00 N/A N/A 0.302±0.00 0.481±0.00 N/A 5.550±3.09 3.626±3.20
ENST00000405623 0.331±0.00 0.275±0.00 0.054±0.00 0.526±0.00 N/A 0.218±0.00 N/A 0.230±0.00 N/A N/A N/A 1.508±0.41 2.062±0.00
ENST00000449220 N/A N/A N/A N/A 0.805±0.00 0.321±0.00 0.347±0.00 N/A N/A N/A 0.166±0.06 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000026 CIL_000026_0002 CGP 2:25042130-25168903

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IDA G-protein coupled receptor binding
GO:0005102 IMP receptor binding
GO:0005179 ISS hormone activity
GO:0005576 IEA:TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005737 ISS cytoplasm
GO:0005782 IDA peroxisomal matrix
GO:0006091 IMP generation of precursor metabolites and energy
GO:0007165 IMP signal transduction
GO:0007218 IEA neuropeptide signaling pathway
GO:0007267 IMP cell-cell signaling
GO:0008217 ISS regulation of blood pressure
GO:0016486 TAS peptide hormone processing
GO:0030141 ISS secretory granule
GO:0031781 IPI type 3 melanocortin receptor binding
GO:0031782 IPI type 4 melanocortin receptor binding
GO:0032098 IMP regulation of appetite
GO:0032720 IDA negative regulation of tumor necrosis factor production
GO:0033059 IMP cellular pigmentation
GO:0034774 TAS secretory granule lumen
GO:0042593 IEA glucose homeostasis
GO:0044267 TAS cellular protein metabolic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0070873 IEA regulation of glycogen metabolic process
GO:0070996 IDA type 1 melanocortin receptor binding
GO:2000852 IEA regulation of corticosterone secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043135 pomca proopiomelanocortin a protein_coding Danio_rerio
ENSDARG00000069307 pomcb proopiomelanocortin b protein_coding Danio_rerio
ENSMUSG00000020660 Pomc pro-opiomelanocortin-alpha protein_coding Mus_musculus

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