C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: discs, large homolog 4 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020886 Dlg4 10090 + 11:70017085-70045532 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018700 Dlg4-003 70018728-70045532 protein_coding
  ENSMUST00000108586 Dlg4-013 70017275-70027062 processed_transcript
  ENSMUST00000108588 Dlg4-001 70018466-70045532 protein_coding
  ENSMUST00000108589 Dlg4-002 70017085-70045532 protein_coding
  ENSMUST00000123687 Dlg4-012 70039821-70044619 nonsense_mediated_decay
  ENSMUST00000124568 Dlg4-008 70023905-70031131 protein_coding
  ENSMUST00000131497 Dlg4-007 70044197-70044718 retained_intron
  ENSMUST00000132597 Dlg4-006 70029742-70039042 protein_coding
  ENSMUST00000133140 Dlg4-004 70017241-70031253 protein_coding
  ENSMUST00000134376 Dlg4-005 70018864-70031149 protein_coding
  ENSMUST00000135916 Dlg4-009 70026824-70030991 protein_coding
  ENSMUST00000138004 Dlg4-011 70030637-70031734 retained_intron
  ENSMUST00000143920 Dlg4-010 70030023-70030910 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018700ENSMUST00000108588ENSMUST00000108589ENSMUST00000123687ENSMUST00000132597ENSMUST00000133140ENSMUST00000134376ENSMUST00000135916
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018700 8.512±4.68 5.834±3.71 7.426±0.15 87.567±30.82 5.801±0.86 2.867±0.93 0.700±0.34 2.434±0.32 0.663±0.28 5.858±1.09 0.569±0.23 7.177±2.50 1.317±0.29 1.032±0.57
ENSMUST00000108588 N/A 1.023±0.01 1.493±0.00 24.067±12.66 0.925±0.00 0.670±0.14 0.259±0.00 0.297±0.00 0.200±0.13 N/A 0.262±0.13 2.791±0.59 0.411±0.00 0.281±0.13
ENSMUST00000108589 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.587±1.29 N/A N/A 0.955±0.70 N/A
ENSMUST00000123687 N/A N/A N/A N/A 2.782±0.00 N/A N/A N/A 0.243±0.00 N/A N/A 7.956±0.00 N/A N/A
ENSMUST00000132597 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.288±0.00 N/A
ENSMUST00000133140 N/A N/A N/A N/A N/A N/A N/A N/A 0.289±0.00 N/A N/A N/A N/A N/A
ENSMUST00000134376 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.773±0.00 N/A
ENSMUST00000135916 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.347±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002091 ISS negative regulation of receptor internalization
GO:0005102 IEA receptor binding
GO:0005198 NAS structural molecule activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005886 IDA plasma membrane
GO:0006461 ISS protein complex assembly
GO:0007204 ISS positive regulation of cytosolic calcium ion concentration
GO:0007626 NAS locomotory behavior
GO:0008021 IDA synaptic vesicle
GO:0008022 ISS protein C-terminus binding
GO:0008328 IDA ionotropic glutamate receptor complex
GO:0014069 IDA:ISS postsynaptic density
GO:0016020 IDA membrane
GO:0016188 IDA synaptic vesicle maturation
GO:0019903 ISS protein phosphatase binding
GO:0030054 IDA cell junction
GO:0030165 ISS PDZ domain binding
GO:0030425 IDA dendrite
GO:0030863 IEA cortical cytoskeleton
GO:0031234 IDA extrinsic component of cytoplasmic side of plasma membrane
GO:0031697 ISS beta-1 adrenergic receptor binding
GO:0031748 ISS D1 dopamine receptor binding
GO:0031812 ISS P2Y1 nucleotide receptor binding
GO:0032281 IDA alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032403 ISS protein complex binding
GO:0032839 ISS dendrite cytoplasm
GO:0033130 ISS acetylcholine receptor binding
GO:0035176 IMP social behavior
GO:0035254 IEA glutamate receptor binding
GO:0035255 IPI ionotropic glutamate receptor binding
GO:0035418 IDA:ISS protein localization to synapse
GO:0035641 IMP locomotory exploration behavior
GO:0042043 NAS neurexin family protein binding
GO:0042220 NAS response to cocaine
GO:0043197 IDA dendritic spine
GO:0044224 IDA juxtaparanode region of axon
GO:0044300 IDA cerebellar mossy fiber
GO:0044306 IDA neuron projection terminus
GO:0044309 IDA neuron spine
GO:0045184 ISS establishment of protein localization
GO:0045202 IDA synapse
GO:0045211 IDA postsynaptic membrane
GO:0048168 NAS regulation of neuronal synaptic plasticity
GO:0048169 IGI regulation of long-term neuronal synaptic plasticity
GO:0050806 ISS positive regulation of synaptic transmission
GO:0050885 IMP neuromuscular process controlling balance
GO:0060076 IDA excitatory synapse
GO:0060997 IDA dendritic spine morphogenesis
GO:0071625 IMP vocalization behavior
GO:0097060 IDA synaptic membrane
GO:0097110 IPI scaffold protein binding
GO:0097113 ISS alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
GO:0097120 ISS receptor localization to synapse
GO:0097481 IDA:ISS neuronal postsynaptic density
GO:2000310 ISS regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential
GO:2000821 IMP regulation of grooming behavior

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039385 dlg4b discs, large (Drosophila) homolog 4b protein_coding Danio_rerio
ENSDARG00000041926 DLG4 (2 of 2) discs, large homolog 4 (Drosophila) protein_coding Danio_rerio
ENSG00000132535 DLG4 discs, large homolog 4 (Drosophila) protein_coding Homo_sapiens

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