C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aurora kinase B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020897 Aurkb 10090 + 11:69045647-69051664 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021277 Aurkb-001 69045652-69051664 protein_coding
  ENSMUST00000108666 Aurkb-002 69045647-69051664 protein_coding
  ENSMUST00000126576 Aurkb-003 69045690-69048296 retained_intron
  ENSMUST00000139457 Aurkb-006 69045671-69048218 processed_transcript
  ENSMUST00000139594 Aurkb-007 69047977-69049073 retained_intron
  ENSMUST00000140531 Aurkb-008 69050563-69051139 processed_transcript
  ENSMUST00000149018 Aurkb-005 69048569-69050737 retained_intron
  ENSMUST00000156373 Aurkb-004 69048528-69049075 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021277ENSMUST00000108666ENSMUST00000126576ENSMUST00000139457ENSMUST00000139594ENSMUST00000140531ENSMUST00000149018ENSMUST00000156373
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021277 2.939±1.83 1.409±0.44 1.212±0.06 13.753±4.47 1.626±1.11 7.568±0.92 0.230±0.08 0.320±0.04 25.412±26.47 1.440±0.29 0.272±0.00 8.255±3.46 14.075±8.98 5.151±1.76
ENSMUST00000108666 N/A 0.498±0.00 N/A 0.137±0.00 1.094±0.00 N/A N/A 0.111±0.01 11.936±0.00 N/A 0.055±0.01 5.463±0.46 2.795±2.08 N/A
ENSMUST00000126576 N/A 1.084±0.14 N/A N/A N/A N/A N/A N/A 0.106±0.02 N/A 0.185±0.00 N/A N/A N/A
ENSMUST00000139457 3.471±0.02 2.344±0.40 N/A N/A 3.745±2.12 14.548±1.65 0.220±0.05 0.413±0.15 0.114±0.03 1.504±0.12 0.050±0.00 15.145±5.42 N/A N/A
ENSMUST00000139594 N/A N/A N/A N/A N/A N/A 0.055±0.00 N/A 0.088±0.04 N/A 0.085±0.02 N/A N/A N/A
ENSMUST00000140531 N/A N/A N/A 0.292±0.00 N/A N/A N/A N/A 0.235±0.00 N/A N/A N/A N/A N/A
ENSMUST00000149018 N/A N/A N/A N/A N/A N/A N/A N/A 0.166±0.02 N/A N/A 8.270±0.00 1.210±0.00 N/A
ENSMUST00000156373 N/A N/A N/A 0.216±0.00 N/A N/A N/A N/A N/A N/A 0.081±0.00 26.093±0.00 23.678±21.63 20.109±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0000776 ISO kinetochore
GO:0000779 IEA condensed chromosome, centromeric region
GO:0000780 IEA condensed nuclear chromosome, centromeric region
GO:0002903 ISS negative regulation of B cell apoptotic process
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 ISS nucleus
GO:0005737 IEA cytoplasm
GO:0005819 IEA spindle
GO:0006468 ISS protein phosphorylation
GO:0007568 IEA aging
GO:0008283 IEA cell proliferation
GO:0009838 ISS abscission
GO:0010369 IDA chromocenter
GO:0030496 IDA midbody
GO:0031565 ISS cytokinesis checkpoint
GO:0031577 IEA spindle checkpoint
GO:0032091 IEA negative regulation of protein binding
GO:0032133 IDA chromosome passenger complex
GO:0032466 ISS negative regulation of cytokinesis
GO:0032467 ISS positive regulation of cytokinesis
GO:0034501 ISS protein localization to kinetochore
GO:0034644 ISS cellular response to UV
GO:0035174 IDA histone serine kinase activity
GO:0036089 ISS cleavage furrow formation
GO:0043146 IEA spindle stabilization
GO:0043988 IDA histone H3-S28 phosphorylation
GO:0045171 IEA intercellular bridge
GO:0046872 IEA metal ion binding
GO:0051256 ISS spindle midzone assembly involved in mitosis
GO:0097431 ISO mitotic spindle pole

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037640 aurkb aurora kinase B protein_coding Danio_rerio
ENSG00000178999 AURKB aurora kinase B protein_coding Homo_sapiens

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