C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: aurora kinase B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000178999 AURKB 9606 - 17:8204733-8210600 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316199 AURKB-002 8204733-8210582 protein_coding
  ENST00000534871 AURKB-003 8204743-8210581 protein_coding
  ENST00000577833 AURKB-012 8205265-8210568 protein_coding
  ENST00000578549 AURKB-005 8204871-8210224 protein_coding
  ENST00000578753 AURKB-015 8204961-8206698 retained_intron
  ENST00000580390 AURKB-014 8206493-8208225 retained_intron
  ENST00000580998 AURKB-013 8204902-8210247 nonsense_mediated_decay
  ENST00000581511 AURKB-008 8206491-8210584 protein_coding
  ENST00000582368 AURKB-011 8206538-8210254 protein_coding
  ENST00000583124 AURKB-007 8209998-8210600 retained_intron
  ENST00000583915 AURKB-009 8207242-8210581 protein_coding
  ENST00000584561 AURKB-010 8206519-8210559 retained_intron
  ENST00000584972 AURKB-016 8204859-8207367 protein_coding
  ENST00000585124 AURKB-001 8204773-8210598 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000316199ENST00000534871ENST00000577833ENST00000578549ENST00000578753ENST00000580390ENST00000580998ENST00000581511ENST00000582368ENST00000584561ENST00000584972ENST00000585124
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000316199 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.951±0.00 4.108±0.00 N/A
ENST00000534871 0.368±0.00 N/A N/A N/A 0.892±0.00 0.216±0.00 0.031±0.00 N/A 0.145±0.00 2.145±0.89 1.437±0.00 0.097±0.00
ENST00000577833 N/A N/A N/A N/A N/A N/A N/A N/A 0.642±0.00 N/A N/A 0.382±0.00
ENST00000578549 N/A N/A N/A N/A N/A 0.033±0.00 0.200±0.00 N/A N/A 15.846±0.00 5.687±0.00 N/A
ENST00000578753 N/A 0.565±0.00 N/A N/A N/A N/A 0.105±0.00 0.080±0.00 N/A N/A N/A N/A
ENST00000580390 N/A N/A 0.029±0.00 1.156±0.00 N/A 0.076±0.00 0.027±0.00 0.045±0.00 N/A N/A N/A N/A
ENST00000580998 N/A N/A N/A 0.377±0.00 N/A N/A N/A N/A 0.520±0.00 N/A N/A N/A
ENST00000581511 N/A N/A N/A 0.633±0.47 N/A N/A N/A N/A N/A 3.275±0.00 N/A 0.377±0.00
ENST00000582368 N/A N/A 0.079±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000584561 N/A N/A N/A N/A N/A N/A N/A N/A 0.426±0.00 N/A N/A N/A
ENST00000584972 0.331±0.00 0.853±0.00 0.086±0.00 1.037±0.00 0.463±0.00 N/A N/A N/A 0.504±0.00 0.077±0.00 1.030±0.00 N/A
ENST00000585124 N/A N/A N/A N/A N/A N/A N/A N/A 0.139±0.00 3.323±2.20 2.579±1.01 0.663±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000278 TAS mitotic cell cycle
GO:0000779 IDA condensed chromosome, centromeric region
GO:0000780 IDA condensed nuclear chromosome, centromeric region
GO:0002903 IDA negative regulation of B cell apoptotic process
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004712 TAS protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005819 TAS spindle
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0007067 IEA mitotic nuclear division
GO:0007568 IEA aging
GO:0008283 IEA cell proliferation
GO:0008608 TAS attachment of spindle microtubules to kinetochore
GO:0009838 ISS abscission
GO:0010369 IEA chromocenter
GO:0016570 TAS histone modification
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030496 IDA midbody
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031565 ISS cytokinesis checkpoint
GO:0031577 IEA spindle checkpoint
GO:0032091 IDA negative regulation of protein binding
GO:0032133 IPI chromosome passenger complex
GO:0032466 ISS negative regulation of cytokinesis
GO:0032467 IEA:IMP positive regulation of cytokinesis
GO:0034501 IMP protein localization to kinetochore
GO:0034644 IDA cellular response to UV
GO:0035174 ISS histone serine kinase activity
GO:0036089 IDA cleavage furrow formation
GO:0043146 IMP spindle stabilization
GO:0043988 ISS histone H3-S28 phosphorylation
GO:0045171 IDA intercellular bridge
GO:0046777 TAS protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0051256 IMP spindle midzone assembly involved in mitosis
GO:0051983 TAS regulation of chromosome segregation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037640 aurkb aurora kinase B protein_coding Danio_rerio
ENSMUSG00000020897 Aurkb aurora kinase B protein_coding Mus_musculus

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