C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021025 Nfkbia 10090 - 12:55489411-55492647 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021413 Nfkbia-201 55489411-55492647 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021413
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021413 30.912±12.80 60.677±5.79 26.250±4.57 9.009±0.95 53.376±27.49 50.918±1.54 17.858±6.47 18.412±3.08 14.878±6.58 78.919±16.36 10.070±1.72 44.335±12.73 16.757±10.63 6.882±0.92

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MF CIL_0008MF_0002 VISTA 12:55314270-55915258
CIL_0008ME CIL_0008ME_0002 VISTA 12:55343542-55944223
CIL_0001RJ CIL_0001RJ_0002 CGP 12:55384222-55492647

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IDA protein import into nucleus, translocation
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IEA plasma membrane
GO:0007253 IEA cytoplasmic sequestering of NF-kappaB
GO:0008139 IEA nuclear localization sequence binding
GO:0010468 IMP regulation of gene expression
GO:0010745 IEA negative regulation of macrophage derived foam cell differentiation
GO:0010875 IEA positive regulation of cholesterol efflux
GO:0010888 IEA negative regulation of lipid storage
GO:0019899 IEA enzyme binding
GO:0031072 IEA heat shock protein binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0031663 IDA lipopolysaccharide-mediated signaling pathway
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032270 IEA positive regulation of cellular protein metabolic process
GO:0032403 IEA protein complex binding
GO:0032495 IDA response to muramyl dipeptide
GO:0032496 IDA response to lipopolysaccharide
GO:0034142 IDA toll-like receptor 4 signaling pathway
GO:0042127 IDA regulation of cell proliferation
GO:0042802 IEA identical protein binding
GO:0042994 IEA cytoplasmic sequestering of transcription factor
GO:0043234 IEA protein complex
GO:0043330 IDA response to exogenous dsRNA
GO:0045638 IMP negative regulation of myeloid cell differentiation
GO:0045746 IMP negative regulation of Notch signaling pathway
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051059 IEA NF-kappaB binding
GO:0070427 IDA nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431 IDA nucleotide-binding oligomerization domain containing 2 signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005481 nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a protein_coding Danio_rerio
ENSDARG00000007693 nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b protein_coding Danio_rerio
ENSG00000100906 NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha protein_coding Homo_sapiens

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