C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: clusterin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022037 Clu 10090 + 14:65968483-65981548 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022616 Clu-001 65968483-65981548 protein_coding
  ENSMUST00000127387 Clu-003 65970620-65975865 protein_coding
  ENSMUST00000128539 Clu-005 65971058-65975777 protein_coding
  ENSMUST00000138191 Clu-004 65970804-65975842 protein_coding
  ENSMUST00000138665 Clu-007 65968642-65975646 nonsense_mediated_decay
  ENSMUST00000144619 Clu-006 65971303-65974962 protein_coding
  ENSMUST00000146990 Clu-008 65968654-65972537 retained_intron
  ENSMUST00000152903 Clu-009 65974669-65975974 retained_intron
  ENSMUST00000153460 Clu-002 65969718-65975961 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022616ENSMUST00000138665ENSMUST00000144619
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022616 61.853±31.77 225.318±43.12 93.973±8.77 13.566±1.56 245.052±100.21 70.603±9.12 387.197±75.74 223.764±28.14 338.226±309.89 170.018±21.48 17.244±6.54 825.221±130.67 34.884±20.32 600.191±274.24
ENSMUST00000138665 N/A N/A N/A 402.689±0.00 N/A N/A N/A N/A N/A N/A N/A 457.745±0.00 N/A N/A
ENSMUST00000144619 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.494±0.00 198.200±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DK CIL_0009DK_0002 VISTA 14:65449305-66050499

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 ISS cell morphogenesis
GO:0001774 ISS microglial cell activation
GO:0005515 IPI protein binding
GO:0005615 ISS extracellular space
GO:0005634 IEA nucleus
GO:0005737 ISS cytoplasm
GO:0005739 IEA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0008219 IEA cell death
GO:0009615 IEA response to virus
GO:0016020 IEA membrane
GO:0017038 ISS protein import
GO:0031012 ISS extracellular matrix
GO:0031410 IEA cytoplasmic vesicle
GO:0031625 ISS ubiquitin protein ligase binding
GO:0032286 ISS central nervous system myelin maintenance
GO:0032436 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463 ISS negative regulation of protein homooligomerization
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0034366 ISS spherical high-density lipoprotein particle
GO:0043065 ISS positive regulation of apoptotic process
GO:0045429 ISS positive regulation of nitric oxide biosynthetic process
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0051131 ISS chaperone-mediated protein complex assembly
GO:0051787 ISS misfolded protein binding
GO:0051788 ISS response to misfolded protein
GO:0061077 ISS chaperone-mediated protein folding
GO:0061518 ISS microglial cell proliferation
GO:0070062 IEA extracellular vesicular exosome
GO:0072562 IEA blood microparticle
GO:0097193 ISS intrinsic apoptotic signaling pathway
GO:0097418 ISS neurofibrillary tangle
GO:0097440 ISS apical dendrite
GO:1900221 ISS regulation of beta-amyloid clearance
GO:1901214 ISS regulation of neuron death
GO:1901216 IMP positive regulation of neuron death
GO:1902004 IMP positive regulation of beta-amyloid formation
GO:1902230 ISS negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 ISS negative regulation of beta-amyloid formation
GO:1902847 ISS regulation of neuronal signal transduction
GO:1902949 ISS positive regulation of tau-protein kinase activity
GO:1902998 ISS positive regulation of neurofibrillary tangle assembly
GO:2000060 ISS positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244 ISS positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010434 clu clusterin protein_coding Danio_rerio
ENSG00000120885 CLU clusterin protein_coding Homo_sapiens

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