C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: clusterin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120885 CLU 9606 - 8:27596917-27615031 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316403 CLU-001 27596917-27615031 protein_coding
  ENST00000405140 CLU-004 27597808-27611431 protein_coding
  ENST00000518050 CLU-014 27608541-27614700 retained_intron
  ENST00000519472 CLU-015 27608937-27614681 protein_coding
  ENST00000519742 CLU-011 27606354-27611966 protein_coding
  ENST00000520491 CLU-016 27606364-27611218 protein_coding
  ENST00000520796 CLU-017 27605141-27611205 protein_coding
  ENST00000521770 CLU-021 27598143-27600015 protein_coding
  ENST00000522098 CLU-020 27598537-27605339 protein_coding
  ENST00000522238 CLU-010 27610476-27614243 protein_coding
  ENST00000522299 CLU-009 27597996-27614693 retained_intron
  ENST00000522413 CLU-013 27606382-27614692 protein_coding
  ENST00000522502 CLU-019 27604218-27605339 retained_intron
  ENST00000523396 CLU-012 27608937-27614698 protein_coding
  ENST00000523500 CLU-003 27597996-27611357 protein_coding
  ENST00000523589 CLU-018 27604310-27614690 protein_coding
  ENST00000560566 CLU-002 27604366-27611751 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000405140ENST00000519472ENST00000521770ENST00000522098ENST00000523500ENST00000523589ENST00000560566
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000405140 52.845±0.00 165.455±0.00 6.847±0.00 458.188±360.21 224.794±0.00 202.612±0.00 12.963±0.00 165.310±27.79 193.393±177.81 33.025±25.38 N/A 185.001±222.39 24.878±3.33 485.087±0.00
ENST00000519472 N/A N/A 164.574±0.00 1649.720±0.00 192.168±0.00 62.029±0.00 55.563±0.00 3569.510±0.00 419.678±0.00 114.410±0.00 12.894±0.00 36.981±28.71 136.882±0.00 800.327±0.00
ENST00000521770 123.068±0.00 429.000±0.00 N/A 1957.720±0.00 541.672±0.00 480.855±0.00 37.349±0.00 464.373±0.00 1163.430±0.00 216.036±0.00 N/A 5.701±0.00 N/A 808.957±289.60
ENST00000522098 57.022±0.00 147.088±0.00 N/A N/A 288.835±0.00 206.852±0.00 25.349±0.00 173.892±0.00 664.208±0.00 202.515±0.00 11.725±6.35 53.941±48.69 55.791±13.00 465.310±0.00
ENST00000523500 N/A N/A N/A N/A N/A 3.025±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000523589 55.795±0.00 150.799±0.00 N/A 1040.310±0.00 259.927±0.00 240.449±0.00 28.877±0.00 204.962±0.00 519.149±0.00 117.799±0.00 13.506±0.00 3.158±0.00 N/A 423.032±0.00
ENST00000560566 N/A N/A 19.003±0.00 227.835±0.00 23.782±0.00 14.117±0.00 4.132±0.00 568.433±0.00 53.633±0.00 29.013±0.00 3.602±0.00 6.317±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0009DK CIL_0009DK_0001 VISTA 8:27594923-28195834
CIL_0005SQ CIL_0005SQ_0002 CGP 8:27596917-27676776

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000902 IDA cell morphogenesis
GO:0001774 IDA microglial cell activation
GO:0001836 IC release of cytochrome c from mitochondria
GO:0002576 TAS platelet degranulation
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005783 IEA endoplasmic reticulum
GO:0006629 NAS lipid metabolic process
GO:0006956 TAS complement activation
GO:0006958 IEA complement activation, classical pathway
GO:0007596 TAS blood coagulation
GO:0008219 IEA cell death
GO:0009615 IEP response to virus
GO:0016020 IEA membrane
GO:0017038 IDA protein import
GO:0030168 TAS platelet activation
GO:0031012 IDA extracellular matrix
GO:0031093 TAS platelet alpha granule lumen
GO:0031625 IDA ubiquitin protein ligase binding
GO:0032286 IMP central nervous system myelin maintenance
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032463 IMP negative regulation of protein homooligomerization
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0034366 IDA spherical high-density lipoprotein particle
GO:0043065 IMP positive regulation of apoptotic process
GO:0043691 TAS reverse cholesterol transport
GO:0045087 IEA innate immune response
GO:0045429 IDA positive regulation of nitric oxide biosynthetic process
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050821 IDA protein stabilization
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051131 IDA chaperone-mediated protein complex assembly
GO:0051787 IDA misfolded protein binding
GO:0051788 IDA response to misfolded protein
GO:0061077 IDA chaperone-mediated protein folding
GO:0061518 IDA microglial cell proliferation
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle
GO:0097193 IDA intrinsic apoptotic signaling pathway
GO:0097418 IDA neurofibrillary tangle
GO:0097440 IDA apical dendrite
GO:1900221 IDA regulation of beta-amyloid clearance
GO:1901214 IDA regulation of neuron death
GO:1901216 IDA positive regulation of neuron death
GO:1902004 ISS positive regulation of beta-amyloid formation
GO:1902230 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902430 IDA negative regulation of beta-amyloid formation
GO:1902847 IMP regulation of neuronal signal transduction
GO:1902949 IMP positive regulation of tau-protein kinase activity
GO:1902998 IMP positive regulation of neurofibrillary tangle assembly
GO:2000060 IMP positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010434 clu clusterin protein_coding Danio_rerio
ENSMUSG00000022037 Clu clusterin protein_coding Mus_musculus

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