C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glial cell line derived neurotrophic factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022144 Gdnf 10090 + 15:7811011-7837575 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022744 Gdnf-201 7811011-7837575 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022744
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022744 1.089±0.76 0.110±0.03 0.123±0.03 0.153±0.02 0.178±0.09 2.051±0.40 0.055±0.02 0.115±0.05 0.008±0.00 2.365±0.29 0.061±0.02 1.582±0.50 0.113±0.07 0.136±0.06

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003LL CIL_0003LL_0002 CGP 15:7811011-8099209

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IGI metanephros development
GO:0001657 IGI ureteric bud development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001755 ISS neural crest cell migration
GO:0001759 IGI organ induction
GO:0001941 IDA postsynaptic membrane organization
GO:0003337 IEP mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005160 TAS transforming growth factor beta receptor binding
GO:0005576 ISS extracellular region
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007399 IMP nervous system development
GO:0007422 IMP peripheral nervous system development
GO:0008083 IEA growth factor activity
GO:0021784 IMP postganglionic parasympathetic nervous system development
GO:0030432 IMP peristalsis
GO:0031175 ISS neuron projection development
GO:0032770 ISS positive regulation of monooxygenase activity
GO:0042803 ISS protein homodimerization activity
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048255 ISS mRNA stabilization
GO:0048484 IMP enteric nervous system development
GO:0048485 IMP sympathetic nervous system development
GO:0051584 ISS regulation of dopamine uptake involved in synaptic transmission
GO:0060676 IMP ureteric bud formation
GO:0060688 IDA regulation of morphogenesis of a branching structure
GO:0072107 ISS positive regulation of ureteric bud formation
GO:0072108 IMP positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:2001240 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039959 gdnfa glial cell derived neurotrophic factor a protein_coding Danio_rerio
ENSG00000168621 GDNF glial cell derived neurotrophic factor protein_coding Homo_sapiens

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