C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glial cell derived neurotrophic factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168621 GDNF 9606 - 5:37812677-37839686 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326524 GDNF-001 37812677-37839680 protein_coding
  ENST00000344622 GDNF-201 37812677-37835491 protein_coding
  ENST00000381826 GDNF-002 37815651-37835827 protein_coding
  ENST00000427982 GDNF-004 37815651-37835827 protein_coding
  ENST00000502572 GDNF-005 37816026-37835491 protein_coding
  ENST00000510177 GDNF-006 37816026-37834908 protein_coding
  ENST00000515058 GDNF-003 37815651-37839686 protein_coding
  ENST00000620847 GDNF-202 37812677-37834822 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000326524ENST00000344622ENST00000510177ENST00000515058
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000326524 N/A N/A N/A N/A N/A 0.536±0.00 N/A N/A N/A N/A 1.617±0.00 0.688±0.63 0.446±0.11 0.048±0.00
ENST00000344622 0.203±0.00 0.061±0.00 0.049±0.00 N/A 0.060±0.00 0.814±0.71 0.079±0.00 0.236±0.00 0.033±0.00 0.074±0.04 1.724±0.00 N/A N/A N/A
ENST00000510177 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.498±0.00 N/A N/A
ENST00000515058 N/A N/A N/A 0.174±0.00 N/A N/A N/A N/A N/A N/A N/A 0.087±0.00 1.192±0.00 0.394±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 ISS metanephros development
GO:0001657 IEA ureteric bud development
GO:0001658 ISS branching involved in ureteric bud morphogenesis
GO:0001755 IDA neural crest cell migration
GO:0001759 IEA organ induction
GO:0001941 IEA postsynaptic membrane organization
GO:0003337 IEA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005102 TAS receptor binding
GO:0005576 IDA extracellular region
GO:0007165 TAS signal transduction
GO:0007399 TAS nervous system development
GO:0007411 TAS axon guidance
GO:0007422 IEA peripheral nervous system development
GO:0008083 IEA growth factor activity
GO:0008344 TAS adult locomotory behavior
GO:0021784 ISS postganglionic parasympathetic nervous system development
GO:0030432 ISS peristalsis
GO:0031175 IDA neuron projection development
GO:0032770 IDA positive regulation of monooxygenase activity
GO:0033603 TAS positive regulation of dopamine secretion
GO:0042803 IDA protein homodimerization activity
GO:0043066 TAS negative regulation of apoptotic process
GO:0043524 IDA negative regulation of neuron apoptotic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048255 IDA mRNA stabilization
GO:0048484 ISS enteric nervous system development
GO:0048485 ISS sympathetic nervous system development
GO:0051584 IDA regulation of dopamine uptake involved in synaptic transmission
GO:0060676 IEA ureteric bud formation
GO:0060688 ISS regulation of morphogenesis of a branching structure
GO:0072107 IDA positive regulation of ureteric bud formation
GO:0072108 IEA positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0090190 IDA positive regulation of branching involved in ureteric bud morphogenesis
GO:2001240 IDA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039959 gdnfa glial cell derived neurotrophic factor a protein_coding Danio_rerio
ENSMUSG00000022144 Gdnf glial cell line derived neurotrophic factor protein_coding Mus_musculus

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