C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: disabled 2, mitogen-responsive phosphoprotein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022150 Dab2 10090 + 15:6299788-6440712 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000078019 Dab2-003 6299788-6440712 protein_coding
  ENSMUST00000080880 Dab2-001 6386598-6440705 protein_coding
  ENSMUST00000110663 Dab2-006 6386776-6439628 protein_coding
  ENSMUST00000110664 Dab2-201 6386748-6440705 protein_coding
  ENSMUST00000159046 Dab2-002 6299813-6416924 protein_coding
  ENSMUST00000159490 Dab2-009 6389050-6418318 protein_coding
  ENSMUST00000159552 Dab2-011 6299788-6435520 processed_transcript
  ENSMUST00000160134 Dab2-012 6386779-6427765 protein_coding
  ENSMUST00000161040 Dab2-004 6299832-6427765 protein_coding
  ENSMUST00000161558 Dab2-013 6423162-6425024 retained_intron
  ENSMUST00000161812 Dab2-007 6386777-6439648 protein_coding
  ENSMUST00000162094 Dab2-010 6390120-6419837 protein_coding
  ENSMUST00000162140 Dab2-005 6299868-6337206 processed_transcript
  ENSMUST00000163082 Dab2-008 6422240-6438907 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000078019ENSMUST00000080880ENSMUST00000110663ENSMUST00000110664ENSMUST00000159552ENSMUST00000160134ENSMUST00000161812ENSMUST00000163082
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000078019 N/A N/A N/A N/A N/A N/A N/A 35.199±5.66 N/A N/A N/A N/A 15.646±0.78 N/A
ENSMUST00000080880 3.072±0.93 N/A 20.813±3.83 2.003±1.41 3.417±1.23 N/A 2.086±0.54 N/A 2.090±1.30 2.589±0.45 1.031±0.27 7.543±0.00 6.596±4.85 0.257±0.07
ENSMUST00000110663 7.953±2.50 27.495±3.86 12.196±0.20 3.673±1.58 10.435±3.25 3.744±1.16 2.493±0.82 87.148±10.42 2.394±1.46 7.167±1.26 0.656±0.09 13.433±5.98 30.363±27.50 0.890±0.10
ENSMUST00000110664 3.331±0.64 15.784±3.34 6.815±0.45 1.640±0.12 4.091±0.00 1.407±0.15 1.404±0.09 N/A 0.681±0.21 4.354±1.43 0.365±0.00 5.595±0.12 12.245±1.69 0.330±0.15
ENSMUST00000159552 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.772±0.00
ENSMUST00000160134 N/A N/A N/A 0.589±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000161812 N/A N/A N/A 0.533±0.00 N/A N/A 1.271±0.00 N/A N/A N/A 0.761±0.00 9.123±0.00 4.476±3.46 0.077±0.00
ENSMUST00000163082 12.453±3.61 59.856±8.40 10.623±0.00 N/A 13.494±0.90 5.877±1.46 3.461±0.35 21.363±0.00 1.977±0.64 9.200±0.95 0.995±0.01 28.450±11.81 6.872±2.29 0.861±0.47

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005E5 CIL_0005E5_0002 CGP 15:6299788-6498751

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000904 IMP cell morphogenesis involved in differentiation
GO:0001701 IMP in utero embryonic development
GO:0001921 IMP positive regulation of receptor recycling
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005178 IMP integrin binding
GO:0005515 IPI protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005905 IEA coated pit
GO:0005925 IEA focal adhesion
GO:0006898 IDA receptor-mediated endocytosis
GO:0006907 IMP pinocytosis
GO:0006915 IEA apoptotic process
GO:0007257 IDA activation of JUN kinase activity
GO:0007492 IMP endoderm development
GO:0007588 IMP excretion
GO:0008022 IEA protein C-terminus binding
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 IEA protein transport
GO:0016055 IEA Wnt signaling pathway
GO:0016324 IDA apical plasma membrane
GO:0030099 IEP myeloid cell differentiation
GO:0030132 IDA clathrin coat of coated pit
GO:0030136 IEA clathrin-coated vesicle
GO:0030276 IDA clathrin binding
GO:0030335 IMP positive regulation of cell migration
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031410 IEA cytoplasmic vesicle
GO:0032091 IEA negative regulation of protein binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 IMP positive regulation of transcription elongation from RNA polymerase II promoter
GO:0035026 IEA leading edge cell differentiation
GO:0035091 IDA phosphatidylinositol binding
GO:0035612 IDA AP-2 adaptor complex binding
GO:0035615 IDA clathrin adaptor activity
GO:0038024 IDA cargo receptor activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045785 IDA positive regulation of cell adhesion
GO:0045807 IEA positive regulation of endocytosis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046332 IEA SMAD binding
GO:0048268 IDA clathrin coat assembly
GO:0060391 IEA positive regulation of SMAD protein import into nucleus
GO:0060766 IEA negative regulation of androgen receptor signaling pathway
GO:0070022 IEA transforming growth factor beta receptor homodimeric complex
GO:0070062 IEA extracellular vesicular exosome
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading
GO:1903077 IMP negative regulation of protein localization to plasma membrane
GO:2000096 IEA positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000370 IDA positive regulation of clathrin-mediated endocytosis
GO:2000643 IEA positive regulation of early endosome to late endosome transport
GO:2001046 IMP positive regulation of integrin-mediated signaling pathway
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031761 dab2 disabled homolog 2 (Drosophila) protein_coding Danio_rerio
ENSG00000153071 DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) protein_coding Homo_sapiens

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