C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: disabled 2, mitogen-responsive phosphoprotein
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000080880 Dab2-001 ENSMUSG00000022150 10090 + 15:6386598-6440705 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastHeartLiverLungMuscleOvaryPlacentaTestisENSMUST00000080880
Transcript ID Adipose Bladder Brain Breast Heart Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000080880 3.072±0.93 20.813±3.83 2.003±1.41 3.417±1.23 2.086±0.54 2.090±1.30 2.589±0.45 1.031±0.27 7.543±0.00 6.596±4.85 0.257±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005E5 CIL_0005E5_0002 CGP 15:6299788-6498751

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000904 IMP cell morphogenesis involved in differentiation
GO:0001701 IMP in utero embryonic development
GO:0001921 IMP positive regulation of receptor recycling
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0005178 IMP integrin binding
GO:0005515 IPI protein binding
GO:0005546 IDA phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 IDA nucleus
GO:0005730 IEA nucleolus
GO:0005737 IDA cytoplasm
GO:0005886 IDA plasma membrane
GO:0005905 IEA coated pit
GO:0005925 IEA focal adhesion
GO:0006898 IDA receptor-mediated endocytosis
GO:0006907 IMP pinocytosis
GO:0006915 IEA apoptotic process
GO:0007257 IDA activation of JUN kinase activity
GO:0007492 IMP endoderm development
GO:0007588 IMP excretion
GO:0008022 IEA protein C-terminus binding
GO:0010718 IMP positive regulation of epithelial to mesenchymal transition
GO:0010862 IMP positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0015031 IEA protein transport
GO:0016055 IEA Wnt signaling pathway
GO:0016324 IDA apical plasma membrane
GO:0030099 IEP myeloid cell differentiation
GO:0030132 IDA clathrin coat of coated pit
GO:0030136 IEA clathrin-coated vesicle
GO:0030276 IDA clathrin binding
GO:0030335 IMP positive regulation of cell migration
GO:0030511 IEA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031410 IEA cytoplasmic vesicle
GO:0032091 IEA negative regulation of protein binding
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968 IMP positive regulation of transcription elongation from RNA polymerase II promoter
GO:0035026 IEA leading edge cell differentiation
GO:0035091 IDA phosphatidylinositol binding
GO:0035612 IDA AP-2 adaptor complex binding
GO:0035615 IDA clathrin adaptor activity
GO:0038024 IDA cargo receptor activity
GO:0043066 IMP negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045785 IDA positive regulation of cell adhesion
GO:0045807 IEA positive regulation of endocytosis
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0046332 IEA SMAD binding
GO:0048268 IDA clathrin coat assembly
GO:0060391 IEA positive regulation of SMAD protein import into nucleus
GO:0060766 IEA negative regulation of androgen receptor signaling pathway
GO:0070022 IEA transforming growth factor beta receptor homodimeric complex
GO:0070062 IEA extracellular vesicular exosome
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:1900026 IDA positive regulation of substrate adhesion-dependent cell spreading
GO:1903077 IMP negative regulation of protein localization to plasma membrane
GO:2000096 IEA positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000370 IDA positive regulation of clathrin-mediated endocytosis
GO:2000643 IEA positive regulation of early endosome to late endosome transport
GO:2001046 IMP positive regulation of integrin-mediated signaling pathway
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000320816 DAB2-001 protein_coding Homo_sapiens 0 2822
ENST00000339788 DAB2-004 protein_coding Homo_sapiens 0 966
ENST00000505968 DAB2-015 retained_intron Homo_sapiens 4.00001e-40 169
ENST00000507539 DAB2-005 nonsense_mediated_decay Homo_sapiens 0 326
ENST00000509337 DAB2-002 protein_coding Homo_sapiens 0 1714
ENST00000512525 DAB2-016 processed_transcript Homo_sapiens 0 601
ENST00000515700 DAB2-007 protein_coding Homo_sapiens 0.00000000000005 82
ENST00000545653 DAB2-201 protein_coding Homo_sapiens 0 1720

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